维生素D结合蛋白与脓毒症关系的研究进展被引量：2

Advances in relationship between vitamin D-binding protein and sepsis

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摘要维生素D结合蛋白(vitamin D-binding protein,VDBP)是一种多功能血浆球蛋白,在结合转运维生素D、清除肌动蛋白、激活巨噬细胞、增强中性粒细胞趋化、激活破骨细胞等免疫炎症反应过程中发挥重要作用。VDBP的血清浓度在脓毒症患者中显著降低,动态观测VDBP血清水平对于预测脓毒症的发生和预后具有重要意义。 Vitamin D-binding protein（VDBP） is a multi-functional plasma protein with many important functions which include transport of vitamin D metabolites, sequestration of actin, macrophage activation, neutrophil chemotaxis and activation of osteoclast in modulating immune and inflammatory responses. The serum concentrations of VDBP in patients with sepsis will decrease remarkably, so it is important for observing the serum levels of VDBP dynamically to predict the occurrence and prognosis of sepsis.

作者张杜超解立新

机构地区解放军总医院呼吸与危重症医学科

出处《解放军医学院学报》 CAS 2016年第4期402-404,共3页 Academic Journal of Chinese PLA Medical School

基金国家自然科学基金面上项目(81370103)~~

关键词维生素D结合蛋白 Gc球蛋白脓毒症 vitamin D binding protein Gc globulin sepsis

分类号 R631 [医药卫生—外科学]

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1Valley TS, Cooke CR. The epidemiology of sepsis : questioning our tmderstattding of the role of race [ J ] . Crit Care, 2015, 19 ( 1 ) : 347.
2Almansa R, Wain J, Tamayo E, et al. Immunological monitoring to prevent and treat sepsis [ J ] . Crit Care, 2013, 17 ( 1 ) : 109.
3White P, Cooke N. The multifunetional properties and characteristics of vitamin D-binding protein [ J ] . Trends Endoerinol Metab, 2000, 11 ( 8 ) : 320-327.
4Swamy N, Head JF, Weitz D, et al. Biochemical and preliminary crystallographic characterization of the vitamin D sterol- and actin- binding by human vitamin D-binding protein [ J ] . Arch Biochem Biophys, 2002, 402 ( 1 ) : 14-23.
5Su L, Cao L, Zhou R, et al. Identification of novel biomarkers for sepsis prognosis via urinary proteomic analysis using iTRAQ labeling and 2D-LC-MS/MS [ J ] . PLoS One, 2013, 8 ( 1 ) : e54237.
6Nagasawa H, Uto Y, Sasaki H, et al. Gc protein ( vitamin D-binding protein ) : Gc genotyping and GcMAF precursor activity [ J ] . Anticancer Res, 2005, 25 ( 6A ) : 3689-3695.
7Perga S, Albo AG, Lis KA, et al. Vitamin D binding protein isoforms and apolipoprotein E in cerebrospinal fluid as prognostic biomarkers of muhiple sclerosis [ J ] . PLoS One, 2015, 10 ( 6 ) : e0129291.
8Chishimba L, Thickett DR, Stockley RA, et al. The vitamin D axis in the lung : a key role for vitamin D-binding protein [ J ] . Thorax, 2010, 65 ( 5 ) : 456-462.
9Ting HJ, Bao BY, Reeder JE, et al. Increased expression of corepressors in aggressive androgen-independent prostate cancer ceils results in loss of 1 alpha, 25-dihydroxyvitamin D3 responsiveness [ J ].Mol Cancer Res, 2007, 5 ( 9 ) : 967-980.
10Hattori N, Oda S, Sadahiro T, et al. YKL-40 identified by proteomic analysis as a biomarker of sepsis [ J ]. Shock, 2009, 32 ( 4 ) : 393- 400.