摘要
目的探讨小剂量右美托咪啶对癫痈手术中唤醒的安全性和有效性。方法 30例癫痈病灶切除术患者随机分为丙泊酚组(P组)和右美托咪啶组(D组),分别在麻醉诱导后行靶控输注丙泊酚(2μg·L^(-1))、右美托咪定(0.4μg·kg^(-1)·h^(-1))。记录诱导前(T1)、唤醒即刻(T2)、配合指令期(T3)、加深麻醉时(T4)、唤醒期结束10 min(T5)麻醉趋势指数(NTI)及心输出量(CO)。结果与D组比较,P组T2、T3、T4时点NTI值降低(P<0.01或0.05),而T2、T4、T5时点CO均明显下降(P<0.01)。结论在癫痈病灶切除术中,小剂量右美托咪啶在唤醒期间心输出量改变较小,且不影响唤醒效果。
Objective To observe the safety and effectiveness of low-dose dexmedetomidine（DEX） in the wake-up test during epileptic surgery.Methods Thirty patients undergoing epileptic surgery were randomly divided into DEX and propofol groups,each receiving DEX（0.4 μg·kg^-1·h%-1） and propofol（2μg·L%-1） after anesthesia induction,respectively.Narcotrend index（NTI） and cardiac output（CO） were recorded at preinduction（TI）,immediate wake-up（T2）,cooperation with instruction（T3）,deep anesthesia（T4）,and 10 min after wake-up（T5）.Results Compared with DEX group,NTI was decreased at T2,T3 and T4（P〈0.01 or 0.05）,while CO was reduced at T2,T4 and T5（P〈0.01） in propofol group.Conclusion Low-dose DEX has little impact on CO and NTI during epileptic surgery.
出处
《广东医学院学报》
2015年第5期612-614,共3页
Journal of Guangdong Medical College
