摘要
目的 观察麻醉诱导前静脉注射地塞米松对手术后静脉芬太尼病人自控镇痛相关恶心呕吐的防治作用。方法 选择 10 0例全麻腹部手术后行静脉芬太尼病人自控镇痛的女性患者 ,随机分为地塞米松组 (Dex组 )和对照组 (Contr组 )。Dex组于麻醉诱导前静脉注射地塞米松 10mg ,Contr组给与等容量生理盐水。双盲法观察术后 2 4h内患者恶心呕吐发生情况和镇痛、镇静效果。结果 术后 2 4h内Dex组恶心呕吐发生率为 36 % ,明显低于Contr组的 6 0 % (P <0 0 5 ) ,且Dex组恶心程度较轻。镇静、镇痛评分无统计学差异。两组均无其它相关并发症。结论 麻醉前静脉注射地塞米松 10mg能有效地降低全麻腹部手术后行静脉芬太尼病人自控镇痛患者的恶心呕吐发生率。
Objective To investigate the effect of dexamethasone on the postoperative nausea and vomiting(PONV) associated with fentany1 patient controlled intravenous analgesia.Methods 100 female patients(n=50 in each group) underwent abdominal surgery under general anesthesia were enrolled in this randomized,double-blinded,placebo-controlled study.The dexamethasone group received dexamethasone 10mg IV before the induction of anesthesia and the control group received placebo(normal saline).The incidence and scores of PONV,scores of sedation and analgesia were evaluated.Results The incidence of PONV in dexamethasone group(36%) was significantly lower than that in control group (60%)(P<0 05) during 24 hours after surgery,and the score of nausea was lower in dexamethasone group.Dexamethasone did not affect the scores of sedation and analgesia.Conclusion Dexamethasone can decrease the incidence of PONV associated with patient controlled intravenous fentany1 analgesia effectively.
出处
《中国医师杂志》
CAS
2002年第8期820-822,共3页
Journal of Chinese Physician
关键词
芬太尼
病人自控镇痛
不良反应
地塞米松
术后恶心呕吐
PCA
Fentanyl
Patient controlled analgesia
Adverse,reaction
Dexamethasone
Postoperative nausea and vomiting
