来曲唑和氯米芬对多囊卵巢综合征所致不孕患者子宫内膜及妊娠率的影响分析被引量：31

Clinical efficacy of letrozole and clomiphene citrate on ovulation induction in the infertile women with polycystic ovary syndrome

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摘要目的:考察多囊卵巢综合征所致不孕患者使用来曲唑和氯米芬对子宫内膜及妊娠率的影响。方法:将200例多囊卵巢综合征所致不孕患者随机分为研究组和对照组,每组100例。对照组患者给予氯米芬治疗,研究组患者给予来曲唑治疗。比较两组患者的生殖激素水平变化、子宫内膜情况以及妊娠率。结果:研究组患者周期第8d的雌二醇水平显著低于对照组、雄烯二酮水平显著高于对照组(P<0.01);h CG日的黄体生成素水平显著高于对照组(P<0.01),雌二醇水平显著低于对照组(P<0.01);研究组患者排卵率和周期妊娠率显著高于对照组(P<0.01,P<0.05);研究组患者成熟卵泡数显著低于对照组(P<0.01),h CG日子宫颈黏液评分、h CG日子宫内膜厚度显著高于对照组(P<0.01)。结论:来曲唑具有促进患者排卵作用,且排卵率高于氯米芬并倾向于单卵发育,对子宫内膜影响较小。 Objectives：To study the clinical effect of letrozole and clomiphene citrate on ovulation induction in the infertile women with polycystic ovary syndrome.Methods：A total of 200 infertile women with polycystic ovary syndrome were randomly divided into study group and control group,with 100 patients in each group.Patients in control group were treated by clomiphene citrate and patients in study group were treated by letrozole.The changes in reproductive hormone levels,endometrial and pregnancy rate were compared between two groups.Results：On the 8-（th） day,the estradiol level in study group was significantly less than that in control group and androstenedione level was significantly higher （P〈0.01）.On the HCG day,the estradiol level in study group was significantly less than that in control group and luteinizing hormone level was significantly higher （P〈0.01）.The ovulation rate and pregnancy rate in study group were significantly higher than those in control group （P〈0.01,P〈0.05）.The number of mature follicles in study group were significantly less than that in control group （P〈0.01）.The cervical mucus score at HCG and endometrial thickness in study group was significantly higher than that in control group （P〈0.01）.Conclusion：Letrozole has a better clinical effect on infertile women with polycystic ovary syndrome,which can improve ovulation,reduce mature follicles and has less influence on endometrium.

作者卢贝琳陈俊卿

机构地区普宁市人民医院妇科普宁市人民医院产科

出处《中国性科学》 2016年第4期126-128,共3页 Chinese Journal of Human Sexuality

关键词多囊卵巢综合征不孕来曲唑氯米芬 Polycystic ovary syndrome Infertile Letrozole Clomiphene citrate

分类号 R711.6 [医药卫生—妇产科学]

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