摘要
目的检测血清胃蛋白酶原Ⅰ(PepsinogenⅠ,PGⅠ)、胃蛋白酶原Ⅱ(PepsinogenⅡ,PGⅡ)及PGⅠ/PGⅡ比值,初步探讨其在胃部疾病中的临床意义。方法所有研究对象均行胃镜检查,部分经病理组织学确诊。取其静脉血血清,采用免疫比浊法检测PGⅠ、PGⅡ及PGⅠ/PGⅡ值,适当分组,进行统计学分析。结果与正常组比较,慢性萎缩性胃炎PGⅠ、PGⅡ值明显升高(P<0.05);胆汁返流性胃炎PGⅠ、PGⅡ及比值变化均不明显,差异无统计学意义(P>0.05)。慢性萎缩性胃炎PGⅡ高于胆汁返流性胃炎(P<0.05)。与幽门螺杆菌(HP)阴性组比较,HP阳性组PGⅡ升高PGⅠ/PGⅡ比值降低(P<0.05)。与病理正常组对照,黏膜慢性活动性炎PGⅡ值升高,PGⅠ/PGⅡ比值降低(P<0.05),肠化生、异型增生,PGⅡ值升高(P<0.05)。结论 PGⅠ、PGⅡ及PGⅠ/PGⅡ值的变化与胃部各种疾病的诊断有一定的关系,对鉴别临床各种胃病具有一定的参考价值。
Objective To detect the value of pepsinogenⅠ（PGⅠ）,pepsinogenⅡ（ PGⅡ） and PGⅠ /PGⅡ ratio in patients with gastric diseases and to evaluate the clinical significance in various gastric diseases. Methods All the research objects were conducted gastroscopy and part of them were confirmed by histopathology. Serum levels of PGⅠ,PGⅡand PGⅠ / PGⅡ ratio were detected in these patients by turbidimetric immunoassay. Then these patients were divided into different groups according to the detection results for statistical analysis. Results Compared with the normal group,PGⅠ and PGⅡ were significantly higher in chronic atrophic gastritis（P〈0. 05）; but the levels of PGⅠ,PGⅡand PGⅠ / PGⅡ ratio in bile reflux gastritis group did not change significantly,the difference had no statistica lsignificance（P〈0. 05）. PGⅡ level in chronic atrophic gastritis was higher than that in bile reflux gastritis,and the differece had statistial significance（ P〉0. 05）. The PGⅡ level increased and PGⅠ / PGⅡ ratio decreased in HP positive group when compared to those in HP negative group（P〈0. 05）. Compared with the pathological normal group,the value of PGⅡ was higher and the ratio of PGⅠ / PGⅡ was lower in mucosal chronic active inflammation group（P〈0. 05）,while PGⅡ level was elevated in intestinal metaplasia and dysplasia（ P〈0. 05）. Conclusion The diagnosis of various gastric diseases is associated with the levels of serum PGⅠ,PGⅡand PGⅠ /PGⅡ ratio, which contributes to discriminate various gastric diseases in clinic.
出处
《中国卫生检验杂志》
北大核心
2014年第9期1272-1273,共2页
Chinese Journal of Health Laboratory Technology
关键词
胃蛋白酶原
胃镜
免疫比浊法
胃部疾病
Pepsinogen
Gastroscopy
Turbidimetric immunoassay
Gastric diseases
