摘要
利马前列素是一种人工合成的前列腺素E1衍生物,有强大的血管舒张和抗血小板聚集作用,能够通过扩张外周血管而改善神经血流。利马前列素临床上主要用于改善与血栓闭塞性脉管炎相关的各种缺血性症状,以及后天获得性腰椎管狭窄相关的行走能力,也用于雷诺综合征及勃起功能障碍等疾病的治疗。本文介绍利马前列素在药理学、药代动力学、动物实验与临床应用等方面的研究现状。
Limaprost,a synthetic prostaglandin E1 derivative,has strong vasodilatory and antiplatelet activity,and can improve nerve blood flows via its peripheral vasodilatory action. Limaprost is primarily used for improvement of various ischemic symptoms associated with thrombo angiitis obliterans and gait ability associated with acquired lumbar spinal canal stenosis,and is beneficial in Raynaud＇s phenomenon and erectile dysfunction et al. This paper introduces the application research progress of limaprost in the pharmacology,pharmacokinetics,animal trials and clinical application.
出处
《中国生化药物杂志》
CAS
2016年第3期16-18,22,共4页
Chinese Journal of Biochemical Pharmaceutics
关键词
利马前列素
药理学
药代动力学
临床应用
进展
limaprost
pharmacology
pharmacokinetics
clinical application
progress
