摘要
缺血再灌注损伤是指缺血组织或器官再次获得血流灌注时对组织、器官造成的损伤作用。而缺血再灌注损伤时，线粒体即可产生的大量的活性氧且线粒体通透性发生改变从而诱发线粒体自噬。线粒体自噬功能的紊乱与机体多种疾病的发生有着密切的关系。本文旨在介绍近年来线粒体自噬的研究进展，重点阐述其在缺血再灌注损伤中的作用及机制。
Isehemia-reperfusion injury （IR） refers to the ischemic tissues or organs to regain perfusion on tissue and organ damage. Tile reactive oxygen species（ROS）generated by the mitochondrial and the change of the mito- chondrial permeability can be induced mitophagy. And dysfunction of the mitophagy is closely related to the body a variety of disease. This article aims to introduce the research of progress about mitophagy in recent years, especially the role it play in the ischemia-reperfusion injury.
出处
《国际外科学杂志》
2016年第3期214-216,共3页
International Journal of Surgery
基金
扬州市科技攻关项目（YZ2009051,YZ2010087）
关键词
自噬
线粒体
缺血再灌注
Autophagy
Mitochondria
Reperfusion injury
