摘要
目的探究对孕产妇实施剖宫产手术后对其预防性应用头孢替唑钠的临床疗效,并就其安全性进行评价。方法随机选取我院90例实施剖宫产手术的患者,根据对患者应用头孢替唑钠时间的不同,将所有患者随机分为两组,即对照组和试验组。其中对照组患者在手术结束后对其静脉滴注头孢替唑钠2.0g Q12h 48h;试验组患者在手术进行中脐带结扎后便立即对其静脉滴注头孢替唑钠2.0g,术后12h再追加头孢替唑钠2.0g。并对两组患者的感染发生率、最高体温、体温恢复正常的时间以及抗菌治疗费用和住院时间长短等临床指标进行对比分析。结果经过治疗后,两组患者在术后最高体温以及体温恢复正常所需时间的比较上,并无明显差异。在伤口感染率以及白细胞或中性粒细胞的升高率的比较上,亦无明显差异。但试验组患者治疗时所需的抗菌药物费用要远远低于对照组,试验组为(114.87±25.51)元,对照组为(229.86±43.57)元。并且住院时间也比对照组明显缩短,两治疗组之间比较差异十分明显,有统计学价值。结论头孢替唑钠应用于剖宫产术中预防性治疗临床效果比较显著,相比于在术后对患者进行多次用药治疗,不仅明显缩短了患者的治疗时间,而且还显著降低了患者的治疗费用,在一定程度上缓解了患者的经济压力,值得在临床广泛推广。
Objective The ceftezole sodium was investigated for its clinically preventative effects on lying- in women who had a caesarean section, and its safety was evaluated. Methods Ninety patients who had had a caesarean section in our hospital were selected on a random basis, and were divided randomly into two group： control group and experimental group, according to different time at which the ceftezole sodium injections were taken. The patients in the control group received ceftezole sodium through intravenous drips after their caesarean section（2.0g, Q12h 48h）, while those in the experimental group took 2.0g intravenous dirp of ceftezole sodium immediately after the umbilical cord was ligatured during the operation, and another 2.0g of ceftezole sodium added 12h after the operation. A contrastive analysis was conducted between the two groups of patients based on some clinical indexes, such as the rate of surgical side infection, the maximum of body temperature, the time for body temperature to return to normal as well as antimicrobial treatment cost and hospital stay duration. Results There were no significant differences found between the two groups of patients regarding the maximum of body temperature and the required time for body temperature to go normal. The comparison regarding wound infection rate and the increase rate of leukocyte or neutrophile granulocyte also showed no evident differences. However, the treatment required far less antibacterial agents cost in the experimental group of patients than in the control group, the former 114.87±25.51 yuan for the former while 229.86±43.57 yuan for the latter. The patients in the experimental group also spent much less time in hospital compared with those in the control group, which difference was sufficient to have statistical values. Conclusion The ceftezole sodium achieved a relatively significant clinical effect of prophylactic treatmentwhen applied in the cesatean section process. It is worth generally promoting in clinical applications for it can not only shorten the curative time for the patients to a large extent, but also lower the treatment costs remarkably to partly relieve patients from economic pressures, both of which are superior to the repeated post-operation medication for patients.
出处
《国外医药（抗生素分册）》
CAS
2016年第2期93-95,共3页
World Notes on Antibiotics
关键词
剖宫产
头孢替唑钠
术中用药
临床疗效
cesarean section
ceftezole sodium
intraoperative medication
clinical curative effect
