摘要
碳青霉烯类抗生素是一类含β-内酰胺结构的新型抗生素,具有广谱的抗菌活性,并且对β-内酰胺酶高度稳定。随着产超广谱β-内酰胺酶(Extended-Spectrumβ-Lactamases,ESBLs)的细菌越来越多,临床上常将碳青霉烯类药物作为ESBLs感染后的有效治疗方法,也因此增加了临床使用此类药物的频率。其直接结果就是导致耐碳青霉烯类抗生素菌株的产生,并且表现为泛耐药。早期报道的对碳青霉烯类耐药的细菌多是铜绿假单胞菌和鲍曼不动杆菌,但是近年来发现了越来越多的耐碳青霉烯类肠杆菌科细菌(Carbapenem-Resisitant Enterobacteriaceae,CRE)。这逐渐成为临床抗感染用药中的难题。因此,对细菌耐药机制进行研究,了解细菌的耐药性,以期待更好的指导临床使用抗生素。
Carbapenem antibiotic is a class of [3-1actam structure of antibiotics, which has broad-spectrum antibacterial activity and beta-lactamase stability. In recent years, more and more extended-spectrum β-1actamases were found, carbapenem antibiotics were clinically abuse. It lead to carbapenem resistant strains emerged frequently. In the early years, only Acinetobacter baumannii and Pseudomonas aeruginosa were found carbapenems-resistant. But in recent years, more and more carbapenems-resistant enterobacteriaceae （CRE） were reported. So we expect to investigate the resistant mechanism of the CRE and provide correct informations to the doctor.
出处
《国外医药（抗生素分册）》
CAS
2016年第2期68-72,共5页
World Notes on Antibiotics
基金
鄂尔多斯市中心医院自主科研项目
项目编号:EY2014013
关键词
耐碳青霉烯类肠杆菌科细菌
碳青霉烯酶
耐药机制
carbapenems-resistant Enterobacteriaceae： carbapenemase
mechanism of drug resistance
