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可诱导细胞凋亡的FKBP12/caspase-9慢病毒载体的构建与应用

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摘要 虽然基因修饰T细胞免疫治疗在癌症治疗中起到积极作用[1-3]。然而,基因修饰T细胞的安全调控是临床治疗需要解决的关键问题,利用自杀基因系统调控基因修饰的细胞是基因治疗的安全措施之一[4-5]。Caspase-9作为凋亡的起始因子,通过化学诱导二聚化将其激活[6],
作者 雷艳杰 孙向东 王春荣 朱武凌 韩双印
机构地区 新乡医学院基础医学院 郑州大学人民医院消化内科 河南中医学院
出处 《细胞与分子免疫学杂志》 CAS CSCD 北大核心 2016年第1期81-83,共3页 Chinese Journal of Cellular and Molecular Immunology
基金 国家自然科学基金(81372405) 河南省基础与前沿项目(132300410036)
关键词 细胞凋亡 二聚化 自杀基因
分类号 R392.11 [医药卫生—免疫学] O251 [理学—数学]
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参考文献24

  • 1Duong C P, Yong C S, Kershaw M H, et al. Cancer immunotherapy utilizing gene-modified T cells : From the bench to the clinic [ J ]. Mol Immunol, 2015, 67(2 PtA) : 46 -57.
  • 2Topalian S L, Wolchok J D, Chan T A, et al. Immunotherapy: The path to win the war on cancer[J] ? Cell, 2015, 161 (2) : 185 - 186.
  • 3Fujiwara H. Adoptive immunotherapy for hematological malignancies using T cells gene-modified to express tumor antigen-specific receptors[J]. Pharmaceuticals ( Basel), 2014, 7 ( 12 ) : 1049 - 1068.
  • 4Jones B S, Lamb L S, Goldman F, et al. Improving the safety of cell therapy products by suicide gene transfer[ J/OL]. Front Pharmacol, 2014, 5: 254. doi: 10. 3389/fphar. 2014. 00254. eCollection 2014.
  • 5Casueci M, Hawkins R E, Dotti G, et al. Overcoming the toxicity hurdles of genetically targeted T cells [ J ]. Cancer Immunol Immunother, 2015, 64(1) : 123 - 130.
  • 6Zhou X, Dotti G, Krance R A, et al. Inducible caspase-9 suicide gene controls adverse effects from alloreplete T cells after haploidentical stem cell transplantation [ J ]. Blood, 2015, 125 ( 26 ) : 4103 -4113.
  • 7Gargett T, Brown M P. The inducible caspase-9 suicide gene system as a "safety switch" to limit on-target, off-tumor toxicities of chimeric antigen receptor T cell [ J/OL ]. Front Pharmacol, 2014, 5 : 235. doi: 10.3389/fphar. 2014.00235. eCollection 2014. Review.
  • 8Mohammadi Z, Shariati L, Khanahmad H, et al. A lentiviral vector expressing desired gene only in transduced cells : an approach for suicide gene therapy[ J]. Mol Biotechnol, 2015, 57(9) : 793 -800.
  • 9Rosenberg S A, Restffo N P. Adoptive cell transfer as personalized immunotherapy for human cancer[ J]. Science, 2015, 348 (6230) : 62 - 68.
  • 10Cheadle E J, Gornall H, Baldan V, et al. CAR T cells: driving the road from the laboratory to the clinic [ J]. Immunol Rev, 2014, 257(1) : 91 -106.

二级参考文献21

  • 1Fujiwara H. Adoptive T-cell therapy for hematological malignancies using T cells gene-modified to express tumor antigen-specific receptors[J]. Int J Hematol, 2014, 99(2) : 123 -131.
  • 2Leuci V, Mesiano G, Gammaitoni L, et al. Genetically redirected T lymphocytes for adoptive immunotherapy of solid tumors [ J ]. CurrGene Ther, 2014, 14(1) : 52 -62.
  • 3Tran CA, Burton L, Russom D, et al. Manufacturing d large manbers d patient-specific T cells for adoptive immunotherapy: an approach to improving product safety, composition, and production capacity[ J ]. J Immunother, 2007, 30(6) : 644 -654.
  • 4Kunert A, Straetemans T, Govers C, et al. TCR-engineered T cells meet new chailenges to treat solid tumors: Choice of antigen, T cell fitness, and sensitization of tumor milieu [ J/OL ]. Front Immunol, 2013, 4: 363.
  • 5Riches JC, JG. Advances in chimc tigen receptor for chronic lymphocytic leukemia[J]. Discov Med, 2013, 16(90) : 295 - 302.
  • 6R_osenberg SA. Raising the bar: the curative potential of human cancer immunotherapy [ J/OL]. Sci Transl Med, 2012, 4 ( 127 ) : 127ps8.
  • 7Turtle C J, Riddell SR. Artificial antigen presenting cells for use in adoptive immunotherapy[ J]. Cancer J, 2010, 16(4) : 374 - 381.
  • 8Yang S, Ji Y, Gattinoni L, et al. Modafing the differentiation status of ex vivo-cultured anti-tumor T cells using cytokine cocktails [ J ]. Cancer Immunol Immunother, 2013, 62(4) : 727 -736.
  • 9Fontana MF, Vance RE. Two signal models in innate immunity [ J ]. Immunol Rev, 2011,243(1) : 26 -39.
  • 10Li Y, Kurlander RJ. Comparison of anti-CD3 and anti-CD28-coated beads with soluble anti-CD3 for expanding human T cells: differing impact on CD8 T cell phenotype and responsiveness to restimulation [J/OL]. J Transl Med, 2010, 8: 104.

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细胞与分子免疫学杂志
2016年 第1期

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