摘要
目的探讨鼻腔-鼻窦鳞状细胞癌(sinonasal s q u a m o u s c el l c a r c i n o m a,S NS C C)中细胞角蛋白13(cytokeratin13,CK13)、细胞角蛋白4(cytokeratin 4,CK4)的表达及与肿瘤临床特征的关系。方法应用免疫组化检测42例SNSCC标本(SNSCC组)及癌旁正常黏膜(对照组)中CK13、CK4的表达,应用图像分析仪比较其吸收度值(A值),进行统计学处理。结果 1CK13在对照组、SNSCC组中的阳性表达率为100.00%、30.95%,与肿瘤的分化程度及随访KPS评分呈正相关;2CK4在对照组、SNSCC组中的阳性表达率分别为100.00%、60.95%,与随访KPS评分呈正相关;随着T分级和临床分期的增加,阳性表达率减弱;随着分化程度的降低,阳性表达率依次减弱;在有、无淋巴结转移组织中的表达差异有统计学意义。结论对CK4、CK13进行检测,对SNSCC的预后判断具有重要意义。
OBJECTIVE To investigate the expression of cytokeratin（CK） 4 and 13 in sinonasal squamous cell carcinoma（SNSCC） and their pathobiological implications for tumor angiogenesis and metastasis.METHODS The expression of CK4 and CK13 was detected by immunohistochemistry in normal and cancerous tissues in 42 cases of SNSCC,integral optical density（A）was measured by computer analysis of images and analyzed by SPSS13.0.RESULTS CK4 and CK13 were expressed significantly higher in normal tissues than in cancerous tissues of SNSCC.Moreover,the expression level of CK4 and CK13 was related to the differentiation of SNSCC,which was higher in the well/middle differentiated ones than in poor ones.The expression of CK4 was significantly associated with the tumor size,clinical stage and cervical lymphatic metastasis in SNSCC.While CK13 had no relationship with these three factors.CONCLUSION The detection of CK-4 and CK-13 might play an important role in the prognostic evaluation of SNSCC.
出处
《中国耳鼻咽喉头颈外科》
CSCD
2016年第2期98-101,共4页
Chinese Archives of Otolaryngology-Head and Neck Surgery
