摘要
目的观察穿心莲内酯总酯磺化物对脓毒症患者血清降钙素原(PCT)浓度的影响并探讨其意义。方法收集符合脓毒症纳入标准的脓毒症患者88例,根据患者病情严重程度分为脓毒症型及严重脓毒症型,各型随机分为治疗组和对照组,其中脓毒症42例(治疗组20例、对照组22例),严重脓毒症46例(治疗组21例、对照组25例)。对照组给予西医常规治疗,治疗组给予西医常规治疗基础上联合穿心莲内酯总酯磺化物,两型各组治疗总疗程均为7天,分别测定各组不同时间段PCT浓度。结果脓毒症及严重脓毒症治疗组治疗后3天、7天PCT浓度均低于对照组(P<0.05),治疗组治疗后各时间段PCT浓度均低于治疗前(P<0.05),且脓毒症治疗组治疗后各时间段PCT浓度明显低于严重脓毒症治疗组(P<0.05)。结论穿心莲内酯总酯磺化物对脓毒症及严重脓毒症患者各时间段血清PCT浓度均具有较好降低作用,是脓毒症及严重脓毒症中医辅助治疗的有效措施之一。
Objective To observe the effect of andrographolide sulfonate ester on PCT concentration in sepsis patients. Methods 88 patients with sepsis were divided into the sepsis group （n = 42 ） and the severe sepsis group （ n = 46） according to the severity of the disease. They were also randomly divided into the treatment group （ n = 41 ） and the control group （ n = 47 ）. There were 20 sepsis cases and 21 severe sepsis cases in the treatment group. The control group was given conventional western medicine treatment, and the treatment group was given routine western medicine combined with andrographolide sulfonate ester. The course of treatment was 7 days, and PCT concentra- tion was measured at different time points. Results The concentration of PCT was lower in the treatment group than in the control group （ P 〈 0. 05 ） at Day 3 and 7 after the treatment, and it was obviously lower than before （ P 〈 0.05 ）. Conclusion Andrographolide sulfonate ester can decrease the concentration of PCT for sepsis patients and severe sepsis patients, which illustrates that it has positive effect to reduce the inflammatory response.
出处
《临床肺科杂志》
2016年第4期709-712,共4页
Journal of Clinical Pulmonary Medicine
