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老年肺癌141例临床分析 被引量:5

Clinical analysis of 141 cases of elderly patients with lung cancer
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摘要 目的探讨老年肺癌患者的临床特点。方法收集经病理明确诊断的老年肺癌患者临床资料,回顾性分析患者年龄、性别、ECOG评分、临床症状、病理类型、临床分期、转移部位、合并症等。结果141例老年肺癌患者平均年龄74.48岁,男女性别比例为4.64:1,ECOG评分0—1分患者占89.36%;主要症状为咳嗽(66.7%)、胸闷(17.7%)、疼痛(17.7%),61%患者为非小细胞肺癌(NSCLC),T1患者仅5.67%,N2—3患者达78.72%,Ⅲ~Ⅳ期患者高达90%以上。肺、胸膜转移最为常见,而远处转移(Mlb)多见于骨、脑、肝脏、肾上腺。合并疾病患者达52.5%。结论老年肺癌患者临床表现无特异性且合并疾病较多,临床分期较晚,但行为状态较好,值得临床进一步关注其早期诊断、治疗及预后。 Objective To investigate the clinical characteristics of elderly patients with lung cancer. Methods The clinical data of 141 cases diagnosed with lung cancer by pathology or cytology were analyzed, including their age, gender, Eastern Cooperative Oneology Group performance status (ECOG PS), symptom, pathology type, TNM stage, metastatic sites and complications. Results The average age was 74. 48, and the ratio of male to female was 4. 64. 89.36% of the patients showed 0 - 1 in ECOG status performance, and the common symptoms were cough (66. 7% ) , chest distress (17. 7% ) and pain( 17.7% ). 61% of the patients were non small cell lung cancer. In regard to TNM stage, only 5.67% showed T1, but 78.72% with N2 - 3 and more than 90% with stage Ⅲ~Ⅳ. Lung and pleura were the most frequent metastatic sites, followed by bone, brain, liver and adrenal gland. 52.5% of the patients had complications. Conclusion Elderly patients with lung cancer have no specific clinical symptoms, but they have much more complications and advanced stages. Their performance status is good, thus, further study should focus on its early diagnosis, treatment and prognosis.
出处 《临床肺科杂志》 2016年第4期622-625,共4页 Journal of Clinical Pulmonary Medicine
关键词 老年 非小细胞肺癌 病理 分期 行为状态 合并症 elderly NSCLC pathology stage performance status complications
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  • 1Torre LA, Bray F, Seigel RL, et al. Global Cancer Statistics, 2012[J]. CA CancerJClin, 2015 ;65:87-108.
  • 2陈万青,郑荣寿,张思维,曾红梅,左婷婷,贾漫漫,夏昌发,邹小农,赫捷.2012年中国恶性肿瘤发病和死亡分析[J].中国肿瘤,2016,25(1):1-8.
  • 3Humphrey LL, Deffebach M, Pappas M,et al. Screening tbr lung cancer with low - dose computed tomography : a systematic review to update the U. S. Preventive Task Force recommendation [ J ]. Ann Intern Med, 2013,159(6) : 411 -420.
  • 4石远凯,孙燕,丁翠敏,王子平,王长利,王正,白冲,白春学,冯继锋,刘晓晴,李方,杨跃,束永前,吴密璐,何建行,张沂平,张树才,陈公琰,罗红鹤,罗荣城,周彩存,周燕斌,庞青松,赵宏,赵琼,顾爱琴,凌扬,黄诚,韩宝惠,焦顺昌,简红.中国埃克替尼治疗非小细胞肺癌专家共识(2015版)[J].中国肺癌杂志,2015,18(7):397-400. 被引量:45
  • 5Caprario LC, Kent DM, Trikalinos TA, et al. Determinants of chemotherapy administration and effects of chemotherapy on sur- vival in elderly patients with small cell lung cancer ( SCLC ) : A SEER- Medicare analysis. JCO, 2011 ASCO Annual Meeting Abstracts 29(15) : 7083.
  • 6陈灏珠.实用内科学[M].11版.北京:人民卫生出版社,2002:2364-2366.
  • 7Chen ZM,Peto R,Iona A,et al. Emerging tobacco -related cancer risks in China: A nationwide, prospective study of 0.5 million a- dults [ J ]. Cancer,2015,121 ( suppl 17 ) :3097 - 106.
  • 8Torte LA, Siegel RL, Ward EM, et al. International variation in lung cancer mortality rates and trends among women[ J ]. Cancer Epidemiol Biomarkers Prev ,2014,23 : 1025 - 1036.
  • 9Youlden DR, Cramb SM, Baade PD. The international epidemiol- ogy of lung cancer: geographical distribution and secular trends [J]. J Thorac Oncol, 2008;3:819 -831.
  • 10Zhou QH, Fan YG, Bu H, et al. China national lung cancer screen- ing guideline with low - dose computed tomography (2015 vet-sion) [ J]. Thorac Cancer,2015,6:812 - 818.

二级参考文献36

  • 1陈科,朴勇瑞,谢国明,张琦,沈燕萍,彭敏,万鹏.同步放化疗加巩固化疗与序贯放化疗治疗老年Ⅲ期非小细胞肺癌的疗效对比[J].中国老年学杂志,2014,34(9):2420-2421. 被引量:30
  • 2Kuo CW, Chen YM, Chao JY, et al. Non-small cell lung cancer in very young and very old patients. Chest,2000,117:354-357.
  • 3Fu JB, Kau TY, Severson RK, et al. Lung cancer in women: analysis of the national Surveillance, Epidemiology, and End Results database. Chest,2005,127:768-777.
  • 4Ramalingam S, Pawlish K, Gadgeel S, et al. Lung cancer in young patients : analysis of a Surveillance, Epidemiology, and End Results database. J Clin Oncol, 1998,16:651-657.
  • 5Mauri D, Pentheroudakis G, Bafaloukos D, et al. Non-small cell lung cancer in the young: a retrospective analysis of diagnosis, management and outcome data. Anticancer Res, 2006,26 : 3175- 3181.
  • 6Henschke CI, Miettinen OS. Women' s susceptibility to tobacco carcinogens. Lung Cancer,2004,43 : 1-5.
  • 7Altundag O, Stewart DJ, Fossella FV, et al. Many patients 80 years and older with advanced non-small cell lung cancer (NSCLC) can tolerate chemotherapy. J Thorac Oncol, 2007,2: 141-146.
  • 8Gridelli C, Langer C, Maione P, et al. Lung cancer in the elderly. J Clin Oncol,2007,25 : 1898-1907.
  • 9Comella P, Gambardella A, Frasci G, et al. Comparison of the safety and efficacy of paclitaxel plus gemcitabine combination in young and elderly patients with locally advanced or metastatic non- small cell lung cancer. A retrospective analysis of the Southern Italy Cooperative Oncology Group trials. Crit Rev Oncol Hematol, 2008,65 : 164-171.
  • 10Albain KS, Crowley J J, LeBlanc M, et al. Survival determinants in extensive-stage non-small cell lung cancer: the Southwest Oncology Group experience. J Clin Oncol,1991,9:1618-1626.

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