摘要
背景与目的随着人口老龄化,老年肺癌的发病率呈上升趋势。统计数据显示在过去的10年中,70岁以上人群中肺癌发生率及死亡率较前增加。本文以70岁作为老年肺癌的分界线,旨在分析影响其预后的因素。方法回顾性分析408例70岁以上老年肺癌患者资料,利用SPSS13.0统计软件进行单因素及COX回归多因素分析,探讨性别、年龄、合并症、症状、病理类型、临床分期、浆膜腔积液、手术、化疗、放疗等因素对生存的影响。结果单因素分析显示症状、临床分期、浆膜腔积液、手术、化疗及化疗周期等因素对预后有影响,COX回归多因素分析显示,临床分期(P<0.001)、手术(P=0.013)、化疗次数(P=0.001)为影响预后的因素。结论老年肺癌在早期可从手术及术后辅助化疗中获益,在晚期进行至少4周期的化疗可延长生存时间。对于老年肺癌单药化疗方案不失为一个较好的选择。浆膜腔积液特别是心包积液会明显影响预后,应积极控制处理积液。
Background and objective With the aging of the population, the incidence of lung cancer in elderly rises. It showed that the incidence and mortality of lung cancer in people over 70 years were increased in the past 10 years. We defined age 70 as boundary line of the elderly patients in lung cancer. The aim of this study is to analyze the factors of affecting prognosis. Methods A retrospective study had enrolled 408 cases of lung cancer aged over 70 and SPSS 13.0 software was used in univariate analysis and COX regression analysis to analyze factors affecting prognosis, such as gender, age, complications, symptoms, pathological type, clinical stage, effusion, surgery, radiotherapy, chemotherapy and so on. Results In univariate analysis, symptoms, stage, effusion, surgery, chemotherapy and chemotherapy cycles showed affecting prognosis significantly. In COX regression analysis, it showed that clinical stage （P〈0.001）, surgery （P=0.013）, chemotherapy cycles （P=0.001） were independent prognostic factors. Conclusion Elderly lung cancer patients could be benefit from surgery and adjuvant chemo-therapy while early stage. At late stage, their survival time may be prolonged when receive chemotherapy at least 4 cycles. Sin-gle-agent chemotherapy would be a good choice for elderly lung cancer. Effusion, particularly, pericardial effusion significantly influenced the prognosis, so that it should be effectively controlled.
出处
《中国肺癌杂志》
CAS
2011年第6期502-506,共5页
Chinese Journal of Lung Cancer
关键词
肺肿瘤
老年病学
预后
Lung neoplasms
Geriatrics
Prognosis
