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B细胞活化因子及其受体介导的信号通路参与类风湿关节炎病理机制研究进展 被引量：16

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摘要 类风湿关节炎（Rheumatoid arthritis,RA）是一种慢性系统性自身免疫病,其病理特征是侵蚀性、对称性关节滑膜组织炎症病变[1,2]。目前RA发病机制仍不清楚,临床上运用抗CD20单抗清除B细胞可有效治疗RA[3],提示B细胞在RA免疫病理中的重要作用。
作者 张凤 张玲玲 魏伟
机构地区 安徽医科大学临床药理研究所
出处 《中国免疫学杂志》 CAS CSCD 北大核心 2016年第2期258-261,共4页 Chinese Journal of Immunology
基金 国家自然科学基金(No.81173075 31100640 81330081 81473223) 中国博士后科学基金(No.2013M540509)资助项目
关键词 B细胞活化因子 类风湿关节炎 细胞亚群 抗瓜氨酸抗体 协同刺激信号 关节滑膜组织 自身免疫病 类风湿因子 抗原提呈细胞 信号通路
分类号 R332 [医药卫生—人体生理学]
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参考文献34

  • 1Guidelli GM, Barskova T, Brizi MG, et al. One year in review: novelties in the treatment of rheumatoid arthritis [ J ]. Clin Exp Rheumato1,2015,33 ( 1 ) : 102-108.
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  • 3Lopez-Olivo MA, Amezaga Urruela M, McGahan L, et al. Rituximab for rheumatoid arthritis [J].Cochrane Database Syst Rev ,2015,1 : CD007356.
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  • 5Moisini I, Davidson A. BAFF: a local and systemic target in autoimmune diseases [ J ]. Clin Exp Immunol, 2009, 158 ( 2 ) : 155-163.
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  • 7Xiao W, Long W, Liu GY, et al. Molecular cloning, expression and functional analysis of B-cell activating factor ( BAFF ) in yellow grouper, Epinephelus awoara [J]. Mol Immunol, 2014,59 ( 1 ) : 64-70.
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二级参考文献35

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  • 6Schiemann B,Gommerman JL,Vora K,et al.An essential role for BAFF in the normal development of B cells through a BCMA-independent pathway[J].Science,2001,293(5537):2111-2114.
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同被引文献180

引证文献16

二级引证文献163

中国免疫学杂志
2016年 第2期

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