丙泊酚复合瑞芬太尼分步靶控输注对脓毒症患者全麻诱导血流动力学的影响被引量：13

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摘要目的观察丙泊酚与瑞芬太尼分步靶控输注对脓毒症患者全麻诱导血流动力学的影响。方法脓毒症患者,ASAⅢ~Ⅳ级,随机分为两组。对照组（C组）：靶控静脉输注血浆靶浓度丙泊酚2mg/L,瑞芬太尼4μg/L;观察组（M组）：分步靶控诱导,丙泊酚从1.0mg/L起递增,梯度为0.5mg/L,瑞芬太尼从2μg/L起递增,梯度为1μg/L,血浆靶浓度同C组。静脉注射顺苯磺阿曲库铵0.15mg/kg,后行气管插管。监测诱导前（T0）、插管前（T1）、插管后即刻（T2）、插管后3min（T3）和插管后5min（T4）各时间点的收缩压（SBP）、舒张压（DBP）、平均动脉压（MAP）、心率（HR）、心指数（CI）及每搏量指数（SVI）。结果 C组SBP、DBP、MAP在T1时点降低,与T0时点及M组相比差异有统计学意义（P〈0.05）;T2~T3时点显著升高,且高于T0时点及M组相应时点（P〈0.05）。两组患者诱导后T1时点CI均明显下降,与T0时点相比差异有统计学意义（P〈0.05）。气管插管后C组T2~T3时点CI均明显高于T0时点及M组（P〈0.05）。C组患者SVI在气管插管前后（T1、T2）均低于T0时点（P〈0.05）。结论丙泊酚复合瑞芬太尼分步靶控输注有利于维持脓毒症患者全麻诱导期间的血流动力学稳定。

作者黄晓光何世武黄淡霞

机构地区广东省潮州市中心医院麻醉科

出处《广东医学》 CAS 北大核心 2016年第1期39-41,共3页 Guangdong Medical Journal

关键词脓毒症靶控输注血流动力学全身麻醉

分类号 R572 [医药卫生—消化系统]

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