摘要
目的:探讨雷替曲塞与奥沙利铂联合治疗老年肠癌的临床疗效。方法:选取中煤集团大屯公司中心医院2010年8月—2014年8月收治的老年肠癌患者100例,按随机数字表法分为2组各50例,对照组患者给予奥沙利铂联合5-氟尿嘧啶/亚叶酸钙治疗,观察组患者给予雷替曲塞联合奥沙利铂治疗,比较2组患者临床治疗效果。结果:观察组患者中,无完全缓解病例,部分缓解23例(46.00%),病情稳定17例(34.00%),病情仍有进展者10例(20.00%),总有效率46.00%;对照组患者中,无完全缓解病例,部分缓解10例(20.00%),病情稳定20例(40.00%),病情仍有进展者20例(40.00%),总有效率20.00%。2组患者的总有效率比较,差异有统计学意义(P<0.05)。患者的不良反应有呕吐、便秘、黏膜炎、贫血、腹泻、粒细胞减少、肝功能损伤和脉管炎,观察组患者不良反应发生率低于对照组,2组的差异有统计学意义(P<0.05)。结论:雷替曲塞与奥沙利铂联合治疗老年肠癌疗效显著,可降低不良反应发生率,值得临床借鉴。
OBJECTIVE： To investigate the clinical efficacy of raltitrexed combined with oxaliplatin in treatment of elderly patients with colorectal cancer. METHODS： 100 elderly patients with colorectal cancer admitted into China Coal Group Datun Company Central Hospital from Aug. 2010 to Aug. 2014 were selected to be divided into two groups by the random number table,with 50 cases in each. The control group were treated with oxaliplatin combined with 5-fluorouracil / leucovorin,while the observation group received raltitrexed combined with oxaliplatin; the clinical efficacy of two group of patients were compared. RESULTS： In the observation group,there were no complete remission cases,23 cases（ 46. 00%） with partial remission,17 cases（ 34. 00%） in stable condition,10 cases（ 20. 00%） still had progression illness and the total effective rate was 46. 00%; while in the control group,there were also no complete remission cases,10 cases（ 20. 00%） with partial remission,20 cases（ 40. 00%） in stable condition,20 cases（ 40. 00%） still had progression illness and the total effective rate was 20. 00%; there was statistically significant difference in response rate between two groups（ P〈 0. 05）. The adverse reactions included vomiting,constipation,mucositis,diarrhea,neutropenia,anemia,liver damage and vasculitis,and the incidence of adverse reactions of observation group was significantly lower than that of control group,with statistically significant difference（ P 〈0. 05）.CONCLUSIONS： Raltitrexed combined with oxaliplatin in treatment of elderly patients with colorectal cancer is effective and can reduce the incidence of adverse reactions. It is worthy of clinical reference.
出处
《中国医院用药评价与分析》
2016年第1期10-12,共3页
Evaluation and Analysis of Drug-use in Hospitals of China
关键词
雷替曲塞
老年肠癌
奥沙利铂
不良反应
Raltitrexed
Elderly colorectal cancer
Oxaliplatin
Adverse reactions
