摘要
目的：评价体外循环（CPB）下冠脉搭桥术后患者脑红蛋白（NGB）和S-100β蛋白浓度的变化。方法：选择择期CPB下行冠脉搭桥手术患者40例,术前ASA分级和NYHA分级均为Ⅱ~Ⅲ级,简明精神状态量表（MMSE）评分≥26分。分别于麻醉诱导后（T0）、复温至36℃（T1）、停CPB后1 h（T2）、6 h（T3）和24 h（T4）采集颈静脉窦血3 m L,采用ELISA法测定血浆NGB和S-100β蛋白浓度;术前1 d及术后3 d测定MMSE评分。结果：与T0时比较,T2~T4时患者血浆NGB和S-100β蛋白浓度明显升高（P〈0.05）,并在T3时点达到高峰;术后3 d MMSE评分低于术前（P〈0.05）。结论：CPB下冠脉搭桥术后患者存在认知功能障碍。血浆NGB和S-100β蛋白浓度升高可能成为早期预测心脏术后脑损伤的指标。
Objective： To investigate the changes of plasma neuroglobin and S-100β protein concentrations in patients undergone coronary artery bypass grafting surgery under cardiopulmonary bypass （CPB）. Methods： Forty patients, American Association of Anesthesiologists （ASA） and New York Heart Association （NYHA） sta- tus II or III, the Mini-Mental State Examination （MMSE, range 0 - 30） score 〉26, undergoing coronary artery bypass grafting surgery with CPB were enrolled. Blood samples were collected immediately at anesthesia induction （T0）, CPB re-warming to 36 ℃ （T1） and 1 h （T2）, 6 h （T3） and 24 h （T4） after CPB, plasmas were obtained for further determination of neuroglobin and S-100℃ protein concentration. MMSE were measured preoperatively and three days after operation. Results： Compared with values in T0, the plasma concentrations of neuroglobin and S-100℃ protein was significantly increased at T2-T4 （P〈0.05）, with peaking at T3. MMSE scoring at 3 d after operation was lower than preoperative baseline （P〈0.05）. Conclusion： Cognitive function is impaired and the plasma neuroglobin and S-100℃ protein levels are increased in patients undergone coronary artery bypass grafting surgery under CPB, these two can be considered as indicators of cerebral injury after cardiopulmonary bypass.
出处
《温州医科大学学报》
CAS
2016年第1期53-55,共3页
Journal of Wenzhou Medical University
基金
温州市科技局科研基金资助项目(Y20140539)
