摘要
目的研究葛根素与复方丹参注射液对外伤性脑梗死（traumatic cerebral infarction，TCI）患者血浆P2选择素（P2selectin，P2S）的影响，从而了解其促进脑功能恢复作用的疗效差别。方法20例TCI患者按就诊顺序分为普通药物组、葛根素组、复方丹参注射液组和联合用药组，观察用药前后患者症状改善程度及血浆P2S水平的变化。结果葛根素组、复方丹参注射液组和联合用药组血浆P2S水平下降程度及其临床格拉斯哥预后评分（GOS）明显大于普通药物组（P〈0．05）。复方丹参注射液和葛根素之间有正性协同交互作用。结论TCI患者血浆P2S治疗前明显高于健康人，治疗后均下降，且三个药物治疗组优于普通药物组。葛根素和复方丹参注射液可明显降低血浆P2S浓度，从而达到降低血液黏度、抑制血小板激活、减轻脑血管痉挛、抑制血栓形成的功效。
Objective To investigate the effect of puerarin and compound salvia injection on ≥2 seleetin change in patients with traumatic cerebral infarction （TCI） so as to understand the difference of their curative effect. Methods Twenty patients with TCI were randomly divided into four groups, ie, conventional treatment group, puerarin group, compound salvia injection group and combined treatment group to observe the improvement of the symptoms （ Glasgow Outcome Scale, GOS） and change of plasma P2 selectin after treatment. Results The symptoms （ GOS score） and level of plasma P2 selectin in the puerarin group, the compound salvia injection group and the combined treatment group were superior to those of the conventional treatment group （ P 〈 0.05 ）. The TCI patients had obviously higher level of plasma P2 seleetin than the healthy persons before treatment. The level of plasma P2 selectin was decreased after treatment, with better cm＇ative effect in three other groups compared with the conventional treatment group. Conclusions There is positive synergistic interaction between puerarin and compound salvia injection. Both puerarin and compound salvia injection can decrease the level of plasma P2 seleetin to reduce the blood viscosity, inhibit the platelet activation, reduce the cerebral vasospasm and inhibit the thrombosis, as contributes to the recovery of the TCI patients.
出处
《中华创伤杂志》
CAS
CSCD
北大核心
2011年第3期210-212,共3页
Chinese Journal of Trauma
关键词
脑损伤
葛根素
丹参
P选择素
Brain injuries
Puerarin
Salvia mihiorrhiza
P-selectin
