摘要
P-糖蛋白是广泛分布于人体正常组织中的转运蛋白,能将内源性、外源性物质及其代谢物排出细胞。其广泛分布及对药物的逆向转运功能,使其在药物的吸收、分布、代谢和排泄方面都具有重要意义。P-糖蛋白可识别和转运在结构、化学性质和药理学特性等方面均不同的化合物,对P-糖蛋白的抑制或诱导可产生P-糖蛋白介导的药物相互作用,导致底物药物的不良反应增加或治疗不足。抑制P-糖蛋白可减少药物外排,以提高抗肿瘤药物的治疗效果,或增加药物在脑组织中的积累量,提高中枢神经系统疾病的治疗效果。关于中药对P-糖蛋白影响的报道日渐增多,本文根据已有的国内外研究,归纳了各种中药及其成分对P-糖蛋白的影响及作用机制,以系统了解并指导该领域的研究,并为临床合理用药提供参考。
P-glycoprotein is a kind of transporting protein which widely expresses throughout the body,acts as a protective barrier that exports numerous endogenous,exogenous compounds and metabolites out of cells.Its extensive distribution and reverse transportation function have great significance on absorption,distribution,metabolism and excretion of drugs.P-glycoprotein could recognize and transport compounds of different structures,chemical properties and pharmacology characteristics.Inhibition or induction on P-glycoprotein may result in P-glycoprotein mediated drugdrug interaction,leading to adverse reactions increased or insufficient treatment of concomitant drugs.The inhibition on P-glycoprotein could also be used to enhance therapeutic effects of chemotherapy drugs by reducing their efflux from cancer cells,or improve therapeutic effects of drugs for central nervous system diseases by increasing the amount of drugs in brain tissues.More and more studies about effects of traditional Chinese medicines on P-glycoprotein have been reported,the influence and the mechanisms of traditional Chinese medicines and their ingredients on P-glycoprotein are summarized in this study,to provide references for related researches and clinical drug use.
出处
《实用药物与临床》
CAS
2016年第1期96-104,共9页
Practical Pharmacy and Clinical Remedies
基金
国家自然科学基金项目(81173659)
关键词
中药
P-糖蛋白
作用
机制
Traditional Chinese medicine
P-glycoprotein
Effects
Mechanism
