摘要
目的分析肿瘤标志物升高的患者行胃肠镜检查病变的检出率。方法收集首都医科大学附属北京友谊医院行肿瘤标志物检测及胃肠镜检查的无症状患者资料,根据肿瘤标志物检测结果将患者分成升高组及正常组,应用1:3匹配的病例对照设计,比较病变检出率的差异。结果 CA199、CA125、CEA水平正常组及异常组之间,异常组的病变检出率有高于正常组的趋势,联合多种肿瘤标志物比较:CA199、CA125及CEA任意一项升高组、CA199及CA125任意一项升高组、CA199及CEA任意一项升高组,癌及高级别瘤变检出率分别为13.22%、14.91%、12.34%,相对应的正常组病例癌及高级别瘤变检出率分别为8.02%、8.90%、7.20%,升高组癌及高级别瘤变的检出率高于对照组,且差异具有显著性(P<0.05)。结论肿瘤标志物升高提示胃肠道肿瘤患病的可能性增加,多种肿瘤标志物联合检测对消化道肿瘤的提示意义更大。对于胃肠道肿瘤的确诊,肿瘤标志物检测不能代替胃肠镜。
Objective To investigate the incidence of gastrointestinal lesions in gastroscopy and colonoscopy in patients with elevated serum tumor markers （CA199, CA125, CEA）. Method Participants were enrolled in Beijing Friendship Hospital who underwent serum tumor marker tests, gastroscopy and colonoscopy.According to the results of tumor markers, the patients were divided into groups of the increased group and the normal group. The researcher applicated 1：3 matched case-control design and compared the detection rate of gastrointestinal lesions. Result The detection rate of gastrointestinal lesions in elevated tumor markers group had a higher trend than the normal group. Multiple tumor markers were combined to analyze： for the elevated tumor markers group （the elevated group of serum CA199, CA125 or CEA, the elevated group of serum CA199 or CA125, the elevated group of serum CA199 or CEA）, the detection rates of cancer and high-grade neoplasia were as follows：13.22%, 14.91%, 12.34%. The corresponding detection rates of normal groups were： 8.02%, 8.90%, 7.20%.The detection rates of cancer and high-grade neoplasia in elevated tumor markers groups were higher than the normal groups, and the difference was statistically significant（P〈0.05）. Conclusion Elevation of tumor markers pointed the increased prevalence of gastrointestinal tumors, multiple tumor markers detection had more significance. For the diagnosis of gastrointestinal tumors, tumor markers could not replace endoscopy.
出处
《中国医刊》
CAS
2016年第1期48-53,共6页
Chinese Journal of Medicine
