摘要
目的分析初治的慢性乙型肝炎病毒(HBV)感染患者的肾功能状况,探讨影响肾功能的危险因素。方法连续入组206例慢性HBV感染患者,其中慢性乙型肝炎(CHB)151例,乙型肝炎肝硬化55例,入组患者既往均未接受过抗病毒治疗。应用最新的CKD-EPI方程评估肾小球滤过率估计值(e GFR),评估入组患者肾功能受损[e GFR<90 m L/(min·1.73 m^2)]的发生率并分析肾功能异常的危险因素。结果 206例慢性HBV感染患者中肾功能受损的发生率为21.85%(45/206),CHB和乙型肝炎肝硬化患者肾功能受损发生率分别为17.88%(27/151)和32.73%(18/55),后者明显高于前者(χ~2=5.205,P=0.023)。年龄(≥50岁)及高血压病史为肾功能受损的独立危险因素。结论部分慢性HBV感染患者在进行抗病毒治疗前已存在肾功能异常,年龄和高血压病史为肾功能受损的危险因素。对慢性HBV感染患者应进行基线肾功能评估并定期监测肾功能。
Objective To assess the renal function of patients with chronic hepatitis B virus（ HBV） infection and to explore the risk factors for renal dysfunction. Methods A total of 206 treatment-nave patients with chronic HBV infection were enrolled,including 151 cases of chronic hepatitis B（ CHB） and 55 cases of liver cirrhosis. The renal function with estimated glomerular filtration rate（ e GFR） was calculated with latest Chronic Kidney Disease Epidemiology Collaboration（ CKD-EPI） equation. The prevalence of renal impairment [e GFR 90 m L /（ min·1. 73 m^2） ]was evaluated and risk factors for renal abnormalities were analyzed. Results The total incidence of renal impairment was21. 85%（ 45 /206）,while it was 17. 88%（ 27 /151） and 32. 73%（ 18 /55） among CHB patients and liver cirrhosis patients,with the latter being significantly higher than the former（ χ~2= 5. 205,P = 0. 023）. Age（ ≥50 years） and history of hypertension were identified as risk factors for renal impairment. Conclusions Renal abnormalities pre-exist in some patients with chronic HBV infection before the initiation of any antiviral treatment. Age and history of hypertension are identified as risk factors for renal impairment. We need to evaluate renal function in patients with chronic HBV infection at baseline and monitor renal function regularly.
出处
《山东大学学报（医学版）》
CAS
北大核心
2016年第1期29-32,37,共5页
Journal of Shandong University:Health Sciences
基金
艾滋病和病毒性肝炎等重大传染病防治和"十二五"国家科技重大专项(2013ZX10004902)
山东省医药卫生科技发展计划(2014WS0424)
关键词
慢性乙型肝炎
肾小球滤过率
肾功能受损
Chronic hepatitis B
Glomerular filtration rate
Renal function impairment
