摘要
目的探讨系统性红斑狼疮(systemic lupus erythematosus,SLE)并发高血压及心脑血管事件的高危因素。方法回顾性分析100例SLE患者的临床资料,采用非条件Logistic回归分析其性别、年龄、病程、皮质类固醇治疗情况、血型、尿素氮(BUN)、肌酐、总胆固醇、高密度脂蛋白、甘油三酯、低密度脂蛋白、IgG、IgA、IgM、补体C3、C4及有无发生高血压及心脑血管事件。结果患者年龄[OR 1.110 per year P=0.001(CI 1.044～1.181)]、皮质类固醇治疗情况、BUN[OR 1.307 per mmol/L P<0.05(CI 1.132～1.508)]、IgM[OR 0.215 per g/L,P=0.021(CI 0.058～0.792)]对患者发生高血压及心脑血管事件有明显统计学影响。结论患者年龄越大、肾功能状况越差,发生高血压及心脑血管事件几率越大,长期皮质类固醇治疗后缓解其发生高血压及心脑血管事件危险度更大,为强危险因子。
Objective To explore the risk factors for later hypertension, coronary artery disease disease and stroke in systemic lupus erythematosus. Methods A retrospective study was conducted of data on the clinical and laboratory in- formation of the patients with SLE （age from 10 to 60） years. Results A number of clinical factors were chosen but on- ly increasing age （OR 1.110; 95%CI 1.044 to 1.181; P = 0.001）, glucocorticoid treatment and BUN （OR 1.307; 95%CI 1.132 to 1.508; P 〈 0.05）, IgM （OR 0.215;95%CI 0.058 to 0.792;P = 0.021） were positively associated with an un- favourable outcome. Conclusion The increasing age, renal funtion and the effects of glucocorticoid treatment were the clinical risk factors for later hypertension, coronary artery disease disease and stroke in systemic lupus erythematosus.
出处
《中国现代医生》
2013年第20期42-44,共3页
China Modern Doctor
关键词
红斑狼疮
高血压
冠状动脉粥样硬化
脑卒中
Lupus erythematosus
Hypertension
Coronary atherosclerosis
Stroke
