摘要
目的探讨乳腺癌患者适形放疗术后医院感染的相关危险因素。方法回顾性分析本院2012年1月至2014年6月收治的行适形放疗的143例乳腺癌患者的临床资料,对比发生医院感染及未发生医院感染的相关危险因素,对存在统计学差异的因素行Logistic多因素回归分析。结果 143例行适形放疗的乳腺癌患者中,18例(12.59%)发生医院感染,其中以呼吸系统感染率最高,其次为皮肤感染率。患者的年龄、是否化疗、化疗周期、白细胞计数、抗生素使用时间、是否合并糖尿病、照射剂量及照射野面积为医院感染的危险因素(P<0.05)。接受化疗、化疗周期≥4周、白细胞计数<1.5×109/L、抗生素使用时间≥20天、合并糖尿病、照射剂量≥50 Gy、照射野面积≥120 cm2是引发乳腺癌患者适形放疗术后医院感染的独立危险因素(P<0.05)。结论乳腺癌患者适形放疗术后医院感染与是否化疗、化疗时间、白细胞数、抗生素使用时间、是否合并糖尿病、照射剂量及照射野面积等因素密切相关,在制订放疗方案及放疗过程中应考虑相关危险因素,并积极干预,尽可能降低患者发生医院感染的风险。
Objective To investigate the risk factors of postoperative nosocomial infection in conformal radiotherapy for breast cancer. Method 143 cases of patients admitted in our hospital with breast cancer and treated with conformal radiation therapy from January 2012 to June 2014 were selected. The clinical data were analyzed retrospectively. Risk factors of nosocomial infection and without nosocomial infection were compared. Multi factor Logistic regression analysis was carried out on the factors with statistical difference. Result In 143 cases of breast cancer patients with conformal radiotherapy, nosocomial infection occurred in 18 patients, with infection rate of 12.59%, which was highest in respiratory system infection. The patient＇s age, whether use of chemotherapy, chemotherapy cycles, white blood cells count, time of antibiotics, whether combined with diabetes mellitus, irradiation dose and irradiation area were the risk factors（P〈0.05）. Receiving chemotherapy, chemotherapy cycles for more than 4 weeks, white blood cell counts 1.5×109/L, antibiotic use over 20 days, combined with diabetes mellitus, irradiation dose more than 50 Gy, irradiation area more than 120 cm2 were independent risk factors of nosocomial infection in conformal radiotherapy for breast cancer（P〈0.05）. Conclusion The postoperative nosocomial infection of conformal radiotherapy in patients with breast cancer is closely related to chemotherapy, chemotherapy time, white blood cell count, time of antibiotics, whether combined with diabetes mellitus, irradiation dose and scope. In the formulation and process of radiotherapy, relevant risk factors should be considered. And active intervention should be taken to reduce the risk of nosocomial infection as far as possible.
出处
《中国医学前沿杂志（电子版）》
2015年第11期93-96,共4页
Chinese Journal of the Frontiers of Medical Science(Electronic Version)
关键词
乳腺癌
适形放射治疗
医院感染
危险因素
Breast cancer
Conformal radiotherapy
Nosocomial infection
Risk factors
