摘要
目的探讨血清人软骨糖蛋白39(YKL-40)和白细胞介素-6(IL-6)在评估慢性阻塞性肺疾病(简称慢阻肺)患者预后中的应用价值。方法选择慢阻肺急性加重期患者60例、缓解期患者50例及体检健康者20例,分别测定YKL-40、IL-6、FEV1%及慢阻肺评估测试分数(CAT),分析其水平变化及相关性。结果与对照组比较,慢阻肺缓解组和急性加重组YKL-40、IL-6及CAT水平均升高,FEV1%均降低(P<0.05);与慢阻肺缓解组比较,急性加重组YKL-40、IL-6及CAT水平均升高,FEV1%均降低(P<0.05)。慢阻肺缓解组和急性加重组血清YKL-40、IL-6水平与FEV1%间存在负相关(P均<0.05),与CAT间存在正相关(P均<0.05)。结论联合检测血清YKL-40和IL-6水平在评估慢阻肺患者预后中具有重要应用价值,但其临界值水平需要进一步研究。
Objective To study the application value of YKL-40 and IL-6 in evaluating the prognosis of patients with chronic obstructive pulmonary disease. Methods The study selected 60 COPD patients at acute period as the group A,50 COPD patients at stable period as the group B and 20 healthy controls as the group C. The value of YKL-40,IL-6,FEV1% and CAT were determined respectively,and the changes and correlation were analyzed. Results The levels of YKL-40,IL-6 and CAT were higher,and the level of FEV1% was lower in the group A and B than in the group C（ P〈0. 05）. The levels of YKL-40,IL-6 and CAT were higher,and the level of FEV1% was lower in the group A than in the group B（ P〈0. 05）. The levels of serum YKL-40 and IL-6 were negatively correlated with FEV1%,and positively correlated with CAT in COPD patients. Conclusion It has important application value for evaluating the prognosis of COPD patients to detect the levels of serum YKL-40 and IL-6.
出处
《临床肺科杂志》
2016年第2期227-230,共4页
Journal of Clinical Pulmonary Medicine
