摘要
目的分析比较抗生素灌洗与碘伏灌洗疗法治疗慢性骨髓炎的临床疗效,探讨其临床适用性。方法选取从2012年3月至2013年8月接受治疗的72例慢性骨髓炎患者,根据随机数表法将患者分为研究组和对照组。对照组采用抗生素灌洗疗法进行治疗,研究组采用碘伏灌洗疗法进行治疗。观察记录两组患者围手术期的各项指标,治疗后引流冲洗液中出现细菌的例数,以及治疗后两组患者的临床疗效。结果研究组患者围手术期的手术时间、住院时间、C反应蛋白变化率、术中出血量和伤口愈合时间等指标均明显少于对照组;研究组术后2 d、4 d、6 d的有菌患者比率明显低于对照组,差异均具有统计学意义(P<0.05);研究组总有效率88.9%,明显高于对照组的69.4%,差异具有统计学意义(P<0.05)。结论碘伏灌洗疗法治疗慢性骨髓炎杀菌效果迅速,有效率高,适合临床推广应用。
Objective To compare the clinical efficacy of antibiotic lavage and povidone- iodine lavage in treatment of patients with chronic osteomyelitis,and to discuss its clinical applicability. Methods A total of 72 patients with chronic osteomyelitis during March 2012 to August2013 were treated with antibiotic lavage or povidone- iodine lavage,they were randomly divided into study group and control group according to the random number table method. Patients in control group were applied with antibiotic lavage for treatment,and patients in study group were given with povidone- iodine lavage for treatment. The results of these two groups were observed and compared The perioperative indicators; the number of cases with bacteria in drainage of flushing fluid and clinical efficacy of patients in these two groups were recorded and compared. Results The duration of hospitalization and other perioperative indicators in patients of study group were significantly less than those of patients in control group;the percentage of patients had bacteria in lavage fluid of study group in 2 d,4 d and 6 d after operation was significantly lower than those of patients in control group,and the difference was statistically significant（ P〈0. 05）. The difference in total efficacy（ 88. 9%） of patients in study group compared with that（ 69. 4%） of patients in control group was statistically significant（ P〈0. 05）. Conclusion The application of povidone- iodine lavage in treatment of patients with chronic osteomyelitis can rapidly kill bacteria,with less recurrence and high efficacy,and it is suitable for long- term clinical application.
出处
《临床和实验医学杂志》
2016年第2期132-134,共3页
Journal of Clinical and Experimental Medicine
基金
陕西省科技厅新技术应用研究项目(2010K12-78)
关键词
慢性骨髓炎
抗生素灌洗
碘伏灌洗
Chronic osteomyelitis
Antibiotic lavage
Lodine lavage
