摘要
星形胶质细胞(astrocytes,Ast)是一种特殊的胶质细胞,其数量约为神经元的10倍,它们连续地分布于整个中枢神经系统,执行着复杂的功能。近年来,随着学者们对星形胶质细胞的深入研究,其新功能不断被发现和证实。研究发现,星形胶质细胞通过分泌前列腺素E2(prostaglandin2,PGE2)、转化生长因子-β1(transforming growth factor-β1,TGF-β1)等胶质因子,调节促性腺激素释放激素(gonadotropin-releasinghormone,Gn RH)神经元的活性和分泌,进而参与对动物繁殖的调控。该文主要综述了星形胶质细胞分泌的PGE2和TGF-β1对Gn RH神经元的调节及其分子机制,试图揭示星形胶质细胞在动物繁殖调控中的作用。
Astrocytes are specialized glial cells that outnumber neurons about 10 to 1. They are continuously distributed throughout the central nervous system and perform complex functions. In recent years, with the further research of astrocytes, new functions of astrocytes in animals were discovered and confirmed. It had been demonstrated that astrocytes participate in the regulation of animal reproduction by secreting PGE2, TGF-β1 or other glial factors to promote the activity and secretion of GnRH neurons. In this review, we mainly summarize the molecular mechanism of PGE2 and TGF-β1 so that can illuminate the roles of astrocytes in the regulation of animal reproduction.
出处
《中国细胞生物学学报》
CAS
CSCD
2015年第12期1672-1678,共7页
Chinese Journal of Cell Biology
