摘要
目的对比紫杉醇脂质体与顺铂周疗方案同步放疗治疗中晚期宫颈癌的效果。方法选取98例中晚期宫颈癌患者,随机分为对照组(顺铂周疗联合放疗)和观察组(紫杉醇脂质体周疗联合放疗)。比较2组患者的治疗结果。结果观察组患者的治疗总有效率为95.92%,对照组为91.84%。观察组患者的骨髓抑制、过敏反应、脱发、胃肠道反应、肌肉关节酸痛的发生率均低于对照组(P<0.05)。结论在中晚期宫颈癌的治疗中,紫杉醇脂质体与顺铂周疗方案同步放疗的疗效相当,但紫杉醇脂质体的毒副反应更小,安全性较高。
Objective To compare the clinical efficacy between weekly cisplatin chemotherapy and paclitaxel liposome plus concurrent radiotherapy in the treatment of patients with middle and advanced cervical cancer. Methods A total of 98 patients with middle and advanced cervical cancer were selected. They were divided into control group（ weekly cisplatin chemotherapy） and observation group（ paclitaxel liposome plus concurrent radiotherapy）. The clinical efficacy was compared between two groups. Results The effective rates were 95. 92% and 91. 84% respectively in the observation group and the control group. The incidence rates of bone marrow suppression,allergic reactions,alopecia,sore muscle and joint in the observation group were significantly lower than those in the control group（ P 0. 05）. Conclusion In the treatment of middle and advanced cervical cancer,the efficacy of weekly cisplatin chemotherapy is equal to the paclitaxel liposome plus concurrent radiotherapy,but paclitaxel liposome has less toxic reaction and higher security.
出处
《实用临床医药杂志》
CAS
2015年第24期53-55,共3页
Journal of Clinical Medicine in Practice
基金
国家自然科学基金面上项目资助(81372433)
关键词
宫颈癌
紫杉醇
顺铂
Middle and advanced cervical cancer
Paclitaxel liposome
Cisplatin
