摘要
目的:探讨硼替佐米周疗方法治疗多发性骨髓瘤的疗效及周围神经病变等相关不良反应。方法:回顾性分析10例多发性骨髓瘤使用硼替佐米周疗病例的疗效。其中初诊6例,复诊4例。全部病例均使用硼替佐米周疗方案:硼替佐米1.3mg/m2第1、8、15及22天静推,沙利度胺75mg第1-35天口服,氟美松15mg第1、2、8、9、15、16、21及22天静推。完成至少2次化疗者可进行评估。结果:10例患者均接受硼替佐米周疗。可评估7例,其中CR 6例,VGPR 1例。无患者出现周围神经病变,不良反应主要为带状疱疹(2/7)。结论:硼替佐米周疗方法治疗初诊多发性骨髓瘤效果良好且不良反应较少,对于治疗复发多发性骨髓瘤的优势有待于进一步评估。
Objective：To investigate the efficacy and adverse effects of once-weekly administration of bortezomib,a chemotherapy regimen in the treatment of multiple myeloma（MM）.Methods： The retrospective analysis was based on 10 cases of multiple myeloma with once-weekly administration of bortezomib.There were 6 cases newly diagnosed,and 4 cases treated diagnosed.All patients were treated with once-weekly administration of bortezomib：bortezomib 1.3mg/m^2 was intravenous injection at the 1st,8th,15th and 22nd day,thalidomide 75mg was taken orally once a day（35 days）,and dexamethasone 15mg was intravenous injection at the 1st,2nd,8th,9th,15th,16th,21st and 22nd day.The patients who completed at least two courses were evaluated.Results： All 10 patients received once-weekly administration of bortezomib.Seven cases could be evaluated with CR of 6 and VGPR of 1.The adverse effect was mainly herpes zoster（2/7）.Conclusion： The effect of once-weekly administration of bortezomib to treat newly diagnosed multiple myeloma is good with less adverse effects and the advantage for the treatment of relapsed multiple myeloma needs further evaluation.
出处
《现代肿瘤医学》
CAS
2012年第11期2369-2372,共4页
Journal of Modern Oncology
基金
中国医师协会临床医学科研专项资金(编号:20111210)
关键词
多发性骨髓瘤
硼替佐米
周疗
疗效
不良反应
multiple myeloma
bortezomib
once-weekly administration
efficacy
adverse effects
