摘要
目的比较两种方式经鼻给予右美托咪定在先天性心脏病婴儿心脏超声检查中的效果。方法采用随机双盲对照研究方法,选取接受心脏超声检查需实施镇静的先天性心脏病患儿40例,ASAⅡ~Ⅲ级,年龄1~12个月。随机分为2组：右美托咪定滴鼻组（A组）和右美托咪定喷鼻组（B组）,A组采用注射器滴鼻,B组采用雾化喷鼻器喷鼻,给予右美托咪定1.5μg/kg。分别在鼻腔给药前（T_0）和鼻腔给药后20 min（T_1）观察记录两组患儿心率（HR）、血氧饱和度（SpO_2）及脑电双频指数（BIS）,记录患儿入睡时间、镇静满意度及不良反应。结果相同时点比较,两组患儿的HR、SpO_2及BIS值比较差异无统计学意义（P〉0.05）;与A组比较,B组患儿镇静后入睡时间缩短,镇静满意度提高,哭闹反应及呛咳反应发生率降低（P〈0.05）。结论与滴鼻相比,在先天性心脏病婴儿心脏超声检查中应用雾化喷鼻器经鼻给予右美托咪定可有效缩短入睡时间,减少不良反应发生并提高镇静满意度。
Objective To compare the sedation effect of two ways intranasal dexmedetomidine on the infants with congenital heart disease. Methods Forty infants with congenital heart disease（ ASAⅡ ~ Ⅲ,aged 1 ~ 12 months）scheduled for cardiac ultrasound under sedation were randomly divided into nasal drip group（ group A） and nasal spray group（ group B）. Group A and group B received intranasal dexmedetomidine 1. 5 μg / kg by two ways. The HR,SpO_2 and BIS were respectively monitored and recorded before sedation（ T_0） and at 20 min after intranasal dexmedetomidine（ T_1）. The time-to-fall-asleep,sedation satisfaction and adverse reaction were recorded. Results There was no significant difference in the HR,SpO_2 and BIS between the two groups at the same time point（ P〉0. 05）. Compared with group A,the time-to-fall-asleep in group B was shorter,the sedation satisfaction was higher,and the adverse reaction significantly decreased（ P〈0. 05）. Conclusion Compared with nasal drip,intranasal spray dexmedetomidine in the cardiac ultrasound sedation of infant with congenital heart disease can shorten the time-to-fall-asleep,enhance the sedation satisfaction and reduce the incidences of adverse reaction.
出处
《实用药物与临床》
CAS
2015年第12期1452-1454,共3页
Practical Pharmacy and Clinical Remedies
基金
贝朗麻醉科学研究基金(BBDF-2014-002)
关键词
右美托咪定
先天性心脏病
婴儿
镇静
Dexmedetomidine
Congenital heart disease
Infant
Sedation
