摘要
目的：探讨超声斑点追踪技术（STI）和G-MPI 在评估心肌梗死猪模型心肌损伤情况及心功能中的相关性和一致性，评价超声STI的应用价值。方法对健康同龄成年雌性藏香猪（8头）开胸，结扎冠状动脉前降支第一对角支，建立心肌梗死模型。分别于冠状动脉结扎术前及术后6、24、48、72和96 h对猪行99 Tcm-MIBI G-MPI及经胸超声心动图，分析左心室心肌各节段的灌注情况，应用超声STI分析左心室不同节段超声短轴水平径向应变峰值（ SR）、圆周应变峰值（ SC）及局部心肌旋转角度（ Rot）；分别测量左心室（ LV） EDV、LVESV及LVEF。采用重复测量方差分析和Pearson相关分析进行数据分析。结果成功建立心肌梗死模型6头。 G-MPI示冠状动脉结扎术后6 h较术前无明显变化或极轻微的灌注稀疏灶，术后24、48、72和96 h左心室心肌前间隔心尖段、前壁心尖段、侧壁心尖段呈灌注稀疏缺损区，缺损面积及范围随时间延长未见明显变化。超声STI示术后6～96 h左心室心肌前间隔心尖段、前壁心尖段、侧壁心尖段的SR、SC及Rot不同程度降低。 G-MPI与超声测定的术前猪LVEF分别为（68±3）％、（70±4）％，相关性良好（r＝0．84，P＜0．05）。术后6～96 h G-MPI测定的LVEF分别为（79±1）％、（80±4）％、（58±2）％、（54±4）％、（57±4）％，超声测定值分别为（76±2）％、（76±3）％、（57±3）％、（55±3）％、（68±6）％，相关性减弱（r＝0．40～0．76，均P＜0．05）。术前及术后二者对LVEDV（F＝64．104、30．069，均P＜0．01）、LVESV（F＝35．186、54．903，均P＜0．01）的测定值随术后时间变化的趋势有较好的一致性。结论超声STI技术可以早期预估心肌受损情况，对受损心肌的运动情况进行定量分析，与G-MPI所测心肌灌注和心功能具有较好的相关性和一致性。
Objective To evaluate the value of speckle tracking imaging（ STI） by investigating the correlation and consistency between two-dimensional STI and 99 Tcm-MIBI G-MPI in the assessment of myo-cardial injury and myocardial infarction （ MI） of swine model. Methods Eight healthy and same-age adult female Tibetan swine were used to establish animal models of MI induced by open-chest ligation of the first diagonal branch of the left anterior descending coronary artery. The swine underwent ultrasonic cardiogram and G-MPI before and at 6, 24, 48, 72 and 96 h after the operation. The myocardial perfusion was evalua-ted. Ultrasonic sectional graphs were collected to analyze ultrasonic short-axis horizontal peak values of sys-tolic radial strain （ SR） and systolic circumferential strain （ SC） and local myocardial rotation angle （ Rot） of different segments of the left ventricle with off-line STI. Left ventricular （ LV） EDV, LVESV, LVEF by G-MPI and ultrasonography were compared. Pearson correlation analysis and repeated measures analysis of variance were used. Results Six models were successfully constructed. Six hours after the coronary artery ligation, the G-MPI showed no significant or very few perfusion defects;24, 48, 72 and 96 h after the liga-tion, G-MPI showed sparseness and defects at the anterior septum, anterior and lateral wall of apical seg-ment of apical segment. The peak strain values of SR, SC and Rot at the anterior septal apical segment,＆amp;nbsp;the anterior and lateral wall of apical segment decreased at different time points after the ligation. Six hours after the coronary artery ligation, the STI was positive. For healthy swine, the LVEF measured with G-MPI and ultrasonic STI showed good correlation （（68±3）% vs （70±4）%, r=0.84, P〈0.05）. The LVEF values of G-MPI and ultrasonic STI at 6, 24, 48, 72, 96 h after the ligation were （79±1）%, （80±4）%, （58±2）%, （54±4）%, （57±4）%, and（76±2）%,（76±3）%,（57±3）%,（55±3）%,（68±6）% （r：0.40-0-76, all P〈0.05）. LVEDV and LVESV measured by the two methods showed variation trends at different time points （ F=64.104, 30-069, 35.186, 54.903, all P〈0.01） with good consistency after the ligation. Conclusions Ultrasonic STI could estimate the myocardial injury at an earlier stage and measure the severity of damaged myocardium quantitatively, and the resluts are in good agreement with myocardial perfusion and function by G-MPI.
出处
《中华核医学与分子影像杂志》
CAS
北大核心
2015年第6期428-433,共6页
Chinese Journal of Nuclear Medicine and Molecular Imaging
基金
四川省卫生厅科研课题（130336）
