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冠状动脉造影狭窄而核素心肌灌注显像阴性患者分析 被引量:15

Normal myocardial perfusion imaging in the presence of significant coronary artery stenosis
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摘要 目的探讨冠状动脉(简称冠脉)造影狭窄而核素心肌灌注显像阴性的影响因素。方法回顾性分析133例冠脉造影显示有狭窄病变而核素运动心肌灌注显像正常患者的检查资料,比较2种检查的差异。结果所有患者均完成了运动负荷心肌灌注显像,其中46例(35%)运动负荷试验达到了满意的次极量运动心率。133例冠脉造影显示单支病变84例(63%),双支病变31例(23%),三支病变17例(13%),单纯左主干病变1例(1%);17例三支病变中有13例(76%)各支血管之间的狭窄程度相差≤20%,显示狭窄病变较均衡。133例患者狭窄冠脉共202支,其中左前降支(LAD)93支(46%)、左回旋支(LCX)52支(26%)、右冠状动脉(RCA)52支(26%),左主干5支(2%);狭窄程度为50%~70%的86支(43%)、>70%~90%的有100支(49%)、>90%~100%的有16支(8%)。结论冠脉造影狭窄而核素心肌灌注显像阴性多出现于运动量不足、轻中度狭窄病变、单支病变及均衡性三支病变患者。 Objective The aim of this study was to investigate the factors which might result in normal myocardial perfusion imaging in the presence of significant coronary artery stenosis. Methods One hundred and thirty-three patients [ mean age of (59 ± 10) years,98 men,35 women] who underwent coronary angiography and myocardial perfusion SPECT were retrospectively analyzed. Results Forty-six (35 % ) patients performed adequate bicycle exercise testing and achieved more than 85 % of their predicted maximal heart rates; while 87 (65%) patients did not. Eighty-four (63%) patients had single coronary stenosis, 31 (23 % ) two-vessel and 17 (13%) three-vessel diseases. The difference in stenosis severity among the vessels in 13 (76%) cases with three-vessel diseases was not more than 20%. There were totally 202 coronary artery stenosis: 93(46% )in left anterior descending coronary artery (LAD) , 52(26% )left circumflex coronary artery (LCX), 52 (26%)right coronary artery (RCA) and 5 (2%)left main coronary artery (LM) disease. Eighty-six(43% ) vessels had 50%-70% stenosis, 100(49%) 〉70%-90% and 16(8% )more than 90%. Conclusion Normal myocardial perfusion imaging with significant coronary artery stenosis can probably due to inadequate exercise, single vessel disease and mild to moderate stenotic lesion.
机构地区 中国医学科学院
出处 《中华核医学杂志》 CAS CSCD 北大核心 2007年第1期23-24,共2页 Chinese Journal of Nuclear Medicine
关键词 冠状动脉疾病 冠状动脉造影术 体层摄影术 发射型计算机 单光子 MIBI Coronary disease Coronary angiography Tomography, emission-computed, single-photon MIBI
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  • 1Klocke F J, Baird MG, Lorell BH, et al. ACC/AHA/ASNC guidelines for the clinical use of cardiac radionuclide imaging: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines. J Am Coil Cardiol, 2003, 42: 1318-1333.
  • 2Caner B, Karanfil A, Uysal U, et al. Effect of an additional atropine injection during dobutamine infusion for myocardial SPECT. Nucl Med Commun, 1997, 18:567-573.
  • 3Thomas GS, Prill NV, Majmundar H, et al. Treadmill exercise during adenosine infusion is safe, results in fewer adverse reaction , and improves myocardial perfusion image quality. J Nuel Cardiol, 2000, 7 : 439-446.
  • 4Vitola JV, Brambatti JC, Caligaris F, et al. Exercise supplementation to dipyridamole prevents hypotension, improves electrocardiogram sensitivity, and increases heart-to-liver activity ratio on ^99Tc^m- sestamibi imaging. J Nucl Cardiol, 2001, 8: 652-659.

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