摘要
目的初步探讨乳腺叶状肿瘤患者的临床预后特点。方法回顾性分析246例女性乳腺叶状肿瘤患者的临床资料，以Kaplan—Meier法和Cox比例风险模型分析影响患者无病生存的因素。结果246例患者中，65例失访。!i6例出现局部复发，5例出现远处转移，1例局部复发伴远处转移。全组患者的中位无病生存时间为39个月。单因素分析结果显示，有无纤维腺瘤病史和初治手术方式与乳腺叶状肿瘤患者的无病生存有关（P〈0．001和P=0．043），而病理类型和初治肿瘤最大径与乳腺叶状肿瘤患者的无病生存无关（P=0．083和P=0．974）。Cox多因素分析结果显示，初治手术方式、有无纤维腺瘤病史及病理类型是影响乳腺叶状肿瘤患者无病生存的独立因素（均P〈0．05）。结论乳腺叶状肿瘤患者的预后相对较好，初治手术方式、有无纤维腺瘤病史及病理类型是影响乳腺叶状肿瘤患者无病生存的独立因素。
Objective To explore the prognosis of benign, borderline and malignant phyllodes tumors of the breast. Methods Data from 246 women with phyllodes tumors of the breast treated in the Cancer Hospital, Chinese Academy of Medical Sciences between January 2002 and December 2012, were collected and analyzed retrospectively. The patients were followed-up for a median of 48 months （ range 1-138 months）. Kaplan-Meier analysis and Cox proportional hazard model were used to analyze the factors affecting the disease-free survival. Results Among the 246 patients, 65 were dropped out from the follow-up. 56 patients had local recurrence, 5 patients had distant metastasis, while one case had both local recurrence and distant metastasis. The median disease-free survival time was 39 months. Kaplan-Meier survival analysis revealed that fibroadenoma history and type of primary surgery were associated to the disease-free survival of phyllodes tumors of the breast （P〈0.001, P= 0.043）, while histological type and primary tumor size had no significant relationship with the disease-free survival （ P = 0. 083, P = 0. 974 ）. The multivariate Cox proportional hazard model showed that type of primary surgery, fibroadenoma history and histological types are all independent factors affecting the disease-free survival （ P = 0. 009, P = 0.001 and P 〈 0. 001 ）. Conclusion Phyllodes tumors of the breast have a relatively good prognosis on the whole. Type of primary surgery, fibroadenoma history and histological type are independent factors predicting the disease-free survival of patients with phyllodes tumors of the breast.
出处
《中华肿瘤杂志》
CAS
CSCD
北大核心
2015年第12期923-927,共5页
Chinese Journal of Oncology
关键词
乳腺肿瘤
叶状肿瘤
病理类型
无病生存时间
复发
Breast neoplasms
Phyllodes neoplasms
Pathological type
Disease-freesurvival
Recurrence
