摘要
作者采用遥测记录皮层电图和同时观察行为的方法,观察了SC1001钠盐的抗癫痫作用。实验结果表明,此药对马桑内酯所致的家兔癫痫有降低发生率、延长潜伏期、减轻发作程度和降低死亡率等作用,尤以延长潜伏期更为显著。
In the present experiment, SC_(1001)Na syn-thesized by West China University of Medi-cal Sciences was used for studying to resistepilepsy induced by coriaria lactone.Forty-two normal male rabbits weighing 1.7-2.5kg were randomly divided into four groups.The animals of the control group receivedcoriaria lactone (3 mg/kg, i.m.). Theanimals in each of the experimental groupswere injected separately with SC_(1001)Na(100,200 and 300mg/kg,i.p.), but thecontrol animals were not injected withSC_(1001)Na.Thirty minutes later, the animalsof the experimental groups were injectedwith the same dose of coriaria lactone asthe control animals. The behavior of allanimals before and after injection wereobserved continuously in 4-5 hours. TheECoG of eight animals of them were obser-ved at the same time with telemetricmethod. The results of experiments indicatedthat SC_(1001)Na is effective on epilepsy in-duced by coriaria lactone, in decreasingseizure rate, lengthening latent period,reducing seizure degree, as well as in de-creasing mortalitv-
出处
《华西医科大学学报》
CAS
CSCD
1989年第1期24-27,共4页
Journal of West China University of Medical Sciences
关键词
SC1001Na
马桑内酯
癫痫
皮层电图
SC_(1001)-Sodium
Coriaria lactone
Electrocorticogram
Epilepsy Rabbit
