摘要
背景:超顺磁氧化铁在生物医学领域应用非常广泛,尤其是靶向诊断和治疗方面。目的:总结超顺磁氧化铁的理化性质、制备方法、表面改性、产品检测及其在生物医学领域的应用。方法:以"superparamagnetic iron oxide,preparation,coprecipitation,surface modification,magnetic resonance imaging contrast agent,fluorescent tracing,targeted therapy"为检索词,检索2000至2012年Sciencedirect、Pub Med数据库的文献;以"超顺磁氧化铁,制备,表面改性,磁共振,荧光示踪,靶向诊断,靶向治疗"为检索词,检索2006至2014年CNKI、万方数据库的文献。结果与结论:超顺磁性纳米颗粒能够通过实验室的方式制备出来,制备方法包括水热法、气相沉淀法、机械球磨法、液相微介质电加热法、溶胶-凝胶法、乳化法、共沉淀法等,并且能够通过表面改性及修饰使其具备不同的特性,应用于生物医学的多个领域,如磁共振对比剂、荧光示踪、纳米颗粒靶向治疗、磁热疗及生物分离等。
BACKGROUND： Superparamagnetic iron oxide has been widely used in biomedical applications,especially in the field of targeted diagnosis and therapy. OBJECTIVE： To summarize the physicochemical property,preparation,surface modification,product testing and biomedical applications of superparamagnetic iron oxide. METHODS： In order to search relevant articles about the physicochemical property and biomedical applications of superparamagnetic iron oxide from Pub Med,Sciencedirect,CNKI and Wanfang databases（from 2000 to 2014）,a computer-based search was performed using the keywords of ＂superparamagnetic iron oxide,preparation,coprecipitation,surface modification,magnetic resonance imaging contrast agent,fluorescent tracing,targeted therapy＂ in English and Chinese,respectively. RESULTS AND CONCLUSION： The superparamagnetic iron oxide can be produced in the laboratory,and the preparation methods include hydrothermal method,vapor deposition method,mechanical milling method,liquid-phase microwave dielectric heating method,sol-gel method,emulsion method,co-precipitation method. Moreover,the superparamagnetic iron oxide can have different properties by surface modification and be applied in many biomedical fields,such as magnetic resonance contrast agent,fluorescent tracer,nanoparticle targeted therapy,hyperthermia and bioseparation.
出处
《中国组织工程研究》
CAS
北大核心
2015年第43期7041-7046,共6页
Chinese Journal of Tissue Engineering Research
基金
湖南省自然科学基金(14JJ2034)
湖南省社发领域科技支撑计划项目(2015SF2020-4)~~
