摘要
近年来,磁性氧化铁靶向纳米载体作为载药系统引起了人们的关注。磁性靶向载药系统和靶向药物治疗的目的是药物载体载药后,在外部磁场的作用下直接靶向富集在肿瘤或病损组织,杀伤病损细胞,对人体无害或减少毒副作用。本文介绍了影响磁纳米颗粒在体内作用的设计参数,并总结了被广泛应用于氧化铁纳米颗粒的制备,表面修饰,功能化的方法及氧化铁纳米载体在靶向载药体系中的应用。
Magnetic targeted nanoveetors have attracted a great deal of interest in the application of drug delivery system in recent years. The purpose of magnetic targeted drug delivery and targeted drug therapy is to transport a drug directly to the centre of tumor or lesion sites under an external magnetic field source and thereby treat it deliberately, with no effects or less effects on the body. This review introduces the design parameters that affect magnetic nanoparticles performance in vivo and summarizes the most commonly used synthetic routes, surface modification, functionaliztion of the magnetic iron oxide delivery system, as well as their use in targeted drug delivery.
出处
《现代生物医学进展》
CAS
2011年第17期3386-3389,共4页
Progress in Modern Biomedicine
基金
国家自然科学基金(No.30872404
30828028)
关键词
磁性氧化铁
靶向
药物载体
纳米粒子
Magnetic iron oxide
target
drug carrier
nanoparticles
