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孕妇高危型人乳头瘤病毒载量和持续时间与宫颈病变的关系 被引量:5

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摘要 目的探讨孕妇从妊娠初期至分娩后宫颈高危型人乳头瘤病毒(HR-HPV)感染的载量与持续时间与其相关宫颈病变的关系。方法 1 368例孕妇在末次月经至分娩后1年取宫颈分泌物,采用杂交捕获第二代技术检测HR-HPV DNA,同时行宫颈细胞学检查和组织病理学检查。结果 1 368例孕妇妊娠初期HR-HPV感染率为26.5%(362/1 368);其中21~40岁组高于其他年龄组(P〈0.05)。感染者中发生宫颈病变者57例,患病率为15.7%(57/362)。其中宫颈上皮内瘤变(CIN)52例,宫颈癌(ICC)5例。ICC和各期CIN的HR-HPV载量比较,差异无统计学意义(P〉0.05)。CIN孕妇分娩后1年HR-HPV转阴率为82.7%(43/52)。分娩后42 d HR-HPV载量较妊娠各期明显减少(P〈0.05),分娩后3个月和1年较妊娠各期明显减少(P〈0.01)。结论HR-HPV的载量与宫颈病变的严重程度无关,分娩后HR-HPV自然转阴率较高,其感染载量逐渐减少直到消除。
出处 《中国妇产科临床杂志》 CSCD 北大核心 2015年第6期550-552,共3页 Chinese Journal of Clinical Obstetrics and Gynecology
基金 重庆市九龙坡区科委社会发展类基金资助项目(201307)
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参考文献8

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