摘要
目的了解和认识宫颈原发性低级别神经内分泌肿瘤Ⅱ级(非典型类癌)的形态学特征及免疫组化表型,分析其诊断与鉴别诊断特点,并探讨其研究进展。方法报道1例宫颈低级别神经内分泌肿瘤的病理学形态、免疫表型特征并复习相关文献。结果肿瘤主要由中等大小、形态较一致的细胞组成,细胞呈多边形、立方形或柱状,排列呈大小不一的片状、巢状和梁索状,并可见菊形团结构形成,细胞异型性较小,核分裂象2个/10HPF。肿瘤部分区域细胞密集成片,细胞呈中等异型,核分裂象10个/10HPF,并见灶状肿瘤性坏死。免疫组化:上皮标记CK(+),四项神经内分泌标记(+)。病理诊断为宫颈低级别神经内分泌肿瘤Ⅱ级(非典型类癌)。低级别神经内分泌肿瘤需要与腺癌鉴别。结论宫颈神经内分泌肿瘤由于组织学类型不同,生物学行为有差异,而对于宫颈原发性低级别神经内分泌肿瘤,值得积累更多的病例,进一步探讨其临床病理特征、生物学行为及更有效的治疗方案。
Objective To understand the pathological features of low-Hospital neuroendocrine tumor,G2（ atypical carcinoid tumor） of the cervix,to analyze its characteristics of diagnosis and differential diagnosis,and to review the advancement of the disease. Methods We reported a case of primary low-grade neuroendocrine tumor of the cervix with its pathological features,immune phenotypes and literature reviews. Results It was mainly composed of uniform cells. The cells showed polygonal,cuboidal or columnar shape with well-differentiated rosettes formation or sheets,nests and cords arrangement with mild atypia and the mitotic activity showed 2 /10 HPF. Some areas of this tumor contained cellular tumor cells with moderate atypia and increased mitotic activity（ 10 /10HPF） and local tumor necrosis; IHC showed that the tumor expressed epithelial marker（ CK） and 4 types of neuroendocrine markers. Therefore primary low-grade neuroendocrine tumor of the cervix,grade2 was diagnosed. Low-grade neuroendocrine tumors were most likely to be confused with adenocarcinoma and needed to be differentiated. Conclusion The biological behavior of neuroendocrine tumors of the cervix varies from different histopathological subtypes. It is essential to collect more cases for further exploration of clinicopathologic features,biological behaviors and effective treatments of these low grade neuroendocrine tumors of the cervix.
出处
《诊断病理学杂志》
CSCD
2015年第10期602-605,共4页
Chinese Journal of Diagnostic Pathology
基金
陕西省科学技术研究发展计划项目(2012k W-32-01)
关键词
类癌
非典型类癌
神经内分泌肿瘤
宫颈
病理
Carcinoid
Atypital
Neuroendocrine tumor
Uterine cervix
Pathology
