摘要
目的:研究早发和晚发型精神分裂症患者灰质体积的异常,寻找精神分裂症早发和晚发影响的脑区。方法:以中南大学湘雅二医院20例正常人、20例早发和20例晚发精神分裂症患者作为研究对象,性别、年龄、受教育程度等分组信息相匹配。对获取的被试脑3D结构像做逐像素分析,采用优化的基于像素的形态学分析方法,图像分割获取脑结构的灰质体积信息,然后采用8mm高斯核进行平滑处理,对平滑后的图像进行双样本t检验,分析早发和晚发精神分裂症患者灰质体积的异常。结果:与正常人相比,精神分裂症早发患者中央前回、梭状回、舌回等相关脑区体积萎缩,颞下回、眶内额上回、额中回前部、顶下缘角回等相关脑区体积增大;而与正常人相比,晚发精神分裂患者背外侧额上回、额中回前部等相关脑区体积增加,梭状回、枕下回、颞上回、颞中回等脑区灰质体积萎缩。结论:精神分裂症患者存在多个脑区的灰质体积异常,而且不同的脑区灰质体积的异常与精神分裂症的发病时间有关。
Objective： To study morphological abnormities in early-onset and late-onset schizophrenia, and to investi-gate the different charateristics of gray matter abnormalities between early-onset and late-onset schizophrenia patients.Methods： An experimental contrast was setup among twenty normal controls, twenty early-onset schizophrenia patientsand twenty late-onset schizophrenia patients. Age, sex and years of education were well matched among three groups. Vox-el-based morphometry analysis was used to explore the morphological characteristics in three groups. Three two sample t-tests was performed to investigate the gray matter alterations in both early-onset and late-onset schizophrenia patients. Results： Compared with the normal controls, it showed decreased grey matter volume in Precentral_R, Fusiform_L and Lin-gual_L, and it increased grey matter volume in Temporal_Inf_R, Frontal_Mid_Orb_L, Parietal_Inf_R, Frontal_Mid_R, Pre-central_R. compared to the normal controls, it showed decreased grey matter in Fusiform_R, Occipital_Inf_R, Tempo-ral_Pole_Sup_L, Temporal_Mid_L, Temporal_Sup_R, Occipital_Inf_R, and a increased grey matter in Frontal_Sup_Orb_L,Frontal_Mid_L. Conclusion： These findings suggest early-onset schizophrenia relate to the gray matter alterations in thefronto-pariental and fronto-temporal systems, while the late-onset schizophrenia may be related with gray matter abnormal-ities in the temporal and occipital regions.
出处
《中国临床心理学杂志》
CSSCI
CSCD
北大核心
2015年第5期839-842,890,共5页
Chinese Journal of Clinical Psychology
基金
青年科学基金项目(81201147)
