摘要
目的 :探讨首发精神分裂症患者的认知功能与精神症状及疗效的关系。方法 :对 16 4例首发精神分裂症患者随机给予氯丙嗪或氯氮平治疗 ;于治疗前分别作韦氏成人智力量表、韦氏记忆量表、铁槽铁钉测验、手指敲击测试、利手测验、动作功能测验、手功能协调测验、连线测验A和B、威斯康星卡片分类测验(WCST)及词语流畅性测验 11项神经心理测查各一次 ,并作BPRS、SANS、功能总体评定量表 (GAF)一次 ;治疗 12周末再评定 1次上述各项检查。结果 :治疗前认知功能与阳性、阴性症状及治疗 12周前后的差值无显著相关性 ,但治疗 12周末的多数认知功能结果与阳性、阴性症状存在显著性相关。结论 :本研究支持精神分裂症的认知功能、阳性症状、阴性症状三组症状群相互独立的假说。
Objective: To assess the relationship of cognitive functioning with symptomatology and treatment outcome of first episode schizophrenia Method: First episode schizophrenic patients (n=164) were administered 11 neuropsychological tests prior to randomly assigned treatment with chlorpromazine or clozapine, Weschler Adult Intelligence Scale, Weschler Memory Scale, Grooved Pegboard Test, Finger Taping Test, Edinburgh Handedness Test, Trail Making Test A and B, Wisconsin Card Sort Test, a motor function test,a hand coordination test and a verbal fluency testClinical status was assessed prior to treatment and 12 weeks after starting treatment using the Brief Psychiatric Rating Scale, a Chinese revision of the Scale for Assessment of Negative Symptoms and the Global Assessment of Functioning ScaleResults: Pre-treatment neurocognitive functioning was not related to the severity of positive or negative symptoms before treatment or to the level of improvement in positive or negative symptoms with treatment, but it was significantly related to the severity of positive and negative symptoms after 12 weeks of treatment Conclusion: These results support the hypothesis that neurocognitive functioning, positive symptoms and negative symptoms are independent symptom cluster in schizophrenia
出处
《中国心理卫生杂志》
CSSCI
CSCD
北大核心
2000年第6期383-385,396,共4页
Chinese Mental Health Journal
基金
"氯氮平和氯丙嗪治疗首发精神分裂症病人随机双盲对照研究"项目
Novartis(诺华)药物公司资助
关键词
首发精神分裂症
精神症状
认知功能
治疗
first-episode schizophrenia neuropsychological function symptomatology
