摘要
目的:探讨脑钠肽(BNP)和N末端脑钠肽前体(NT-proBNP)的含量变化对呼吸困难患者的鉴别诊断价值。方法:选择入院时呼吸困难患者150例,分为心源性呼吸困难组(心源性组,51例),肺源性呼吸困难组(肺源性组,47例)和肺源性呼吸困难加心源性呼吸困难组(心肺源性组,52例)。另选择正常体检者40例作为正常对照组。观察比较各组治疗前后BNP和NT-proBNP的含量。结果:治疗前,与正常对照组比较,心源性组,心肺源性组和肺源性组的血浆BNP和NT-proBNP含量均显著升高,且心源性组的显著高于肺源性组和心肺源性组,心肺源性组的显著高于肺源性组的,P均<0.01;治疗前心源性组,心肺源性组,肺源性组的NT-proBNP含量依次为[(3356.6±321.2)pg/ml比(3156.9±239.8)pg/ml比(2563.7±234.20)pg/ml],组间比较P均<0.01;出院1周后,3组的血浆BNP和NT-proBNP含量均较治疗前显著降低,仍是心源性组的BNP含量最高,肺源性组的最低,心肺源性组的居中,组间比较,P均<0.01。结论:血浆BNP和NT-proBNP含量有助于鉴别诊断呼吸困难是否属于心源性或肺源性疾病。
Objective： To explore differential diagnosis value of changes of brain natriuretic peptide （BNP） and N ter- minal pro brain natriuretic peptide （NT-proBNP） concentrations in patients with dyspnea. Methods： A total of 150 patients with dyspnea at hospitalization were enrolled and divided into cardiogenic dyspnea group （CD group, n = 51）, pulmonary dyspnea group （PD group, n = 47） and cardiogenic plus pulmonary dyspnea group （CPD group, n = 52）. Another 40 healthy subjects were regarded as normal control group. Concentrations of BNP and NT-proBNP were observed and compared among all groups before and after treatment. Results： Before treatment, compared with normal control group, there were significant rise in plasma concentrations of BNP and NT-proBNP in CD group, CPD group and PD group, that of CD group was significantly higher than those of PD group and CPD group, and that of CPD group was significantly higher than that of PD group, P〈0.01 all . Before treatment, the NT- proBNP content in CD group, CPD group, PD group were [ （3356. 6±321.2） pg/ml vs. （3156. 9 ± 239. 8） pg/ml vs. （2563.7 ±234.20） pg/ml] respectively, comparison among three groups, P〈0.01 all. Compared with before treatment, one week after discharge, plasma concentrations of BNP and NT-proBNP significantly reduced in CD group, CPD group and PD group, the plasma BNP and NT-proBNP concentrations of CD group were the highest, those of PD group were the lowest, and those of CPD group were the middle, P〈0.01 all. Conclusion.. Plasma BNP and NT-proBNP concentrations are helpful to differential diagnose whether dyspnea belongs to cardiogenic or pul- monary diseases.
出处
《心血管康复医学杂志》
CAS
2015年第5期547-550,共4页
Chinese Journal of Cardiovascular Rehabilitation Medicine
基金
黑龙江省卫生厅科研课题(2009-327)~~
关键词
利钠肽
脑
呼吸困难
诊断
鉴别
Natriuretic peptide, brain
Dyspnea
Diagnosis, differential
