摘要
目的探讨诱导痰液中神经生长因子（nerve growth factor，NGF）水平与哮喘患儿病情严重程度的关系。方法将170例哮喘患儿分为两组，其中慢性持续组87例与急性发作组83例，治疗前行肺功能检查，随即取诱导痰，以酶联免疫吸附法检测诱导痰中NGF水平，并且行嗜酸性粒细胞（EOS）计数，最后进行比较分析。结果慢性持续期与急性发作期的NGF、FEVl、FVC、PEF及EOS差异均有统计学意义（均P〈0．05）；慢性持续期和急性发作期患儿的NGF、FEV1、FVC、PEF及EOS在不同严重程度两两之间差异均有统计学意义（均P〈0．05）；NGF与慢性持续期、急性发作期的病情严重程度具有正相关性（均P〈0．05）；NGF与慢性持续期FEVl、FVC、PEF、及EOS具有相关性（均P〈0．05）；NGF与急性发作期的FEV1与PEF具有相关性（均P〈0．05）；NGF与急性发作期的FVC与EOS无相关性（均P〉0．05）。结论哮喘患儿急性发作期较慢性持续期的哮喘患儿诱导痰液中NGF水平升高，NGF水平与急性发作期及慢性持续期患儿的哮喘严重程度存在相关性。
Objective To explore the relationship between bronchial asthma severity and the levels of nerve growth factor（ NGF） in induced sputum. Methods One hundred and seventy children with asthma were divided into two groups, including 87 cases of chronic duration group and 83 cases of acute phase group. Before treatment lung function test was conducted, induced sputum was taken immediaitely, the levels of NGF were measured by enzyme-linked immunosorbent assay and Eosinophils （EOS）in induced sputum were count. Comparative analysis was conducted. Results The levels of NGF,FEV1 ,FVC,PEF and EOS in duration group were significantly elevated compared with acute phase group （ all P 〈 0. 05 ）. Significant differences in NGF, FEV1, FVC,PEF and Eos were found by comparison of different extent in chronic duration group and acute phase group （ all P 〈 0. 05 ）, the levels of NGF were positive correlated with illness severity （ all P 〈 0. 05 ） in children with afsthma in chronic duration and acute phase, the levels of NGF were positive correlation with FEV1, FVC, PE- Fand EOS （ all P 〈 0. 05 ） in children with asthma in chronic duration, the levels of NGF were positive correla- tion with FEV1 and PEF in children with Asthma in acute phase,but the levels of NGF has no correlation with FVC and EOS （ all P 〉 0. 05） in children with Asthma in acute phase. Conclusion The levels of NGF in in- duced sputum of children with asthma in acute phase are markedly elevated compared with children with asthma in chronic duration, the levels of NGF are positive correlated with illness severity in children with asthma in chronic duration and acute phase.
出处
《国际儿科学杂志》
2015年第5期578-581,共4页
International Journal of Pediatrics
关键词
哮喘
儿童
神经生长因子
肺功能
Asthma
Children
Nerve growth factor
Lung function
