摘要
肝脏是重要的免疫与代谢器官。脓毒症并发的多脏器功能障碍综合征中，肝脏是最重要的靶器官之一。脓毒症合并肝损伤时预后差，病死率高。微小RNA（MicroRNA）为非编码小RNA，通过结合目标mRNA，转录后参与基因调控。通过调节免疫反应信号通路，调节炎症因子的产生，以及调控免疫细胞功能等，微小RNA可在脓毒症发病过程的多个层次上发挥调节作用。在调节脓毒症的微小RNA中，微小RNA-155与脓毒症造成的肝损伤关系密切，该综述对此进行概述。
The liver is a crucial organ involved in immune and metabolic processes. In multiple organ dysfunction syndrome secondary to sepsis, liver is one of the target organs. Sepsis-associated liver injury worsens the prognosis and mortality. MicroRNAs are single-stranded, non-coding RNAs. MicroRNAs modulate gene expression post-transcriptionally by binding themselves to complementary sites of target genes and degradation proteins. MicroRNAs affect sepsis pathogenesis at multiple levels through regulating signaling pathways and inflammarion factors in immune reaction, as well as functions of immune cells. Among microRNAs involved in sepsis pathogenesis,microRNA-155 is critical in sepsis associated liver injury and it is sketchily described in this review.
出处
《国际儿科学杂志》
2015年第5期541-544,共4页
International Journal of Pediatrics
