摘要
线粒体是真核生物进行能量代谢的主要场所,在自由基产生、细胞凋亡、衰老等生理病理活动中也起到重要作用。线粒体功能受核基因和线粒体基因共同调控,microRNA(miRNA)介导的基因转录后调控是重要机制之一。核基因编码的miRNA不仅可以通过调控核基因编码的线粒体相关蛋白的表达影响线粒体结构和功能,而且可以进入线粒体并调控线粒体基因的表达。另一方面,线粒体基因也可能编码miRNA,直接调控线粒体基因表达或转运至胞质调控核基因的表达。
Mitochondria are the energy powerhouse of the cell, and they play an important role in other physiological and pathological process, such as free radical production, cell apoptosis and aging. MiRNA-mediated post-transcriptional regulation of gene expression is one of the important mechanisms that regulate mitochondria functions which rely on the crosstalk between nuclear genome and mitochondrial genome. The nuclear encoded miRNA not only regulates the structure and function of mitochondria through modulating mitochondrial-related proteins encoded by the nuclear genome, they can also translocate into the mitochondria and regulate mitochondrial genome expression. Besides, the mitochondrial genome may also encode miRNA that could be immediately active on the mitochondrial transcripts or exported in the cytosol in order to interfere with genomic mRNA.
出处
《中国细胞生物学学报》
CAS
CSCD
北大核心
2013年第1期92-97,共6页
Chinese Journal of Cell Biology
基金
国家重大科学研究计划(批准号:2012CB966800D)
国家自然科学基金(批准号:30971599/C060503)
教育部新世纪优秀人才支持计划(批准号:NCET-06-0526)资助的课题~~
