期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

P糖蛋白在白血病多药耐药中的调控机制 被引量：5

The regulatory mechanisms of P-glycoprotein in leukemia of multi-drug resistance
原文传递
导出
摘要 多药耐药（multidrug resistance，MDR）是导致白血病化疗失败的主要原因，白血病MDR的产生与细胞膜表面P糖蛋白（P-glycoprotein，P—gp）的药物转运作用直接相关，多种信号传导通路如MAPKs、NF-KB、Hedgehog、Wnt／β-catenin、PDK／Akt参与调节P-gp的表达，而调控因子Stats、microRNA、TRAIL、HDACs也与P-gp的表达密切相关。该文就白血病MDR细胞中P-gp的表达调控机制的研究进展作一综述。 Multidrug resistance （MDR）has been a main reason for the failure of leukemia chemotherapy. The generation of MDR in leukemia is directly related to the transportation of drug efflux of P-glycoprotein （P-gp）on cell membrane surface. Many signaling pathways such as MAPK,NF-κB,Hedgehog,Wnt/β-catenin, and PI3K/Akt involves in regulating of P-gp expression. Meanwhile,regulation factors including Stats,microR- NA,TRAIL and HDACs are closely related to the P-gp expression. This review briefly discusses the progress of the regulatory mechanisms of P-gp in MDR of leukemia.
作者 陈洁汝 贾秀红
机构地区 滨州医学院附属医院儿科
出处 《国际儿科学杂志》 2015年第5期499-502,506,共5页 International Journal of Pediatrics
基金 山东省自然科学基金（ZR2014HL032）
关键词 P糖蛋白 白血病 多药耐药 P-glycoprotein Leukemia Multi-drug resistance
分类号 R733.7 [医药卫生—肿瘤]
  • 相关文献

参考文献33

  • 1苏萌,叶启东.白血病靶向治疗的研究进展[J].国际儿科学杂志,2014,41(3):270-273. 被引量：9
  • 2Peng H,Yuan X,Shi R,et al.PHH-7 inhibits cell growth and induces apoptosis in leukemia cell line K562 as well as its MDR-counterpart K562/A02 through producing reactive oxygen species[J].Eur J Pharmacol,2013,718(1-3):459468.
  • 3Wang H,Wang X,Li Y,et al.The proteasome inhibitor bortezomib reverses P-glycoprotein-mediated leukemia multi-drug resistance through the NF-kappaB pathway[J].Pharmazie,2012,67(2):187-192.
  • 4Zhang W,Chen BA,Jin JF,et al.Involvement of c-Jun N-terminal kinase in reversal of multidrug resistance of human leukemia cells in hypoxia by 5-bromotetrandrine[J].Leuk Lymphoma,2013,54(11):2506-2516.
  • 5Zhou H'Ma H,Wei W,et al.B4GALT family mediates the multidrug resistance of human leukemia cells by regulating the hedgehog path- way and the expression of p-glycoprotein and multidrug resistance-as- sociated protein I[J].Cell Death Dis,2013,4:e654.
  • 6Fenner KS,Troutman MD,Kempshall S,et al.Drug-drug interactions mediated through p-glycoprotein:clinical relevance and in vitro-in vi- vo correlation using digoxin as a probe drug[J].Clin Pharmacol T- her,2009,85(2):173-181.
  • 7Li X,Miao H,Zhang Y,et al.Bone marrow microenvironment con- fers imatinib resistance to chronic myelogenous leukemia and orxylin A reverses the resistance by suppressing Stat3 pathway[J].Arch Toxicol,2015,89(1):121-136.
  • 8Farawela HM,Khorshied MM,Kassem NMf et al.The clinical rele- vance and prognostic significance of adenosine triphosphate ATP- binding cassette(ABCB5)and multidrug resistance(MDRl)genes expression in acute leukemia?? an Egyptian study[J],J Cancer Res Clin Oncol,2014,140(8):1323-1330.
  • 9Wang L,Meng Q,Wang C,et al.Dioscin restores the activity of the anticancer agent adriamycin in multidrug-resistance human leukemia K562/adriamycin cells by down-regulating MDRl via a mechanism involving NF-kB signaling inhibition"].J Nat Prod,2013,76(5):909-914.
  • 10Shen H,Xu W,Chen Q,et al.Tetrandrine prevents acquired drug re- sistance of K562 cells through inhibition of mdrl gene transcription [J].J Cancer Res Clin Oncol,2010,136(5):659-665.

二级参考文献80

  • 1CHEN Hong1,CHEN Qun2,FANG Ming3 & MI Yan1 1 The First Affiliated Hospital of Harbin Medical University,Harbin 150101,China,2 Harbin Acheng District People’s Hospital,Harbin 150300,China,3 Graduate Department of Harbin Medical University,Harbin 150001,China.microRNA-181b targets MLK2 in HL-60 cells[J].Science China(Life Sciences),2010,53(1):101-106. 被引量：20
  • 2中华医学会儿科学会急救学组.第四届全国小儿急救医学研讨会纪要[J].中华儿科杂志,1995,33:370-370.
  • 3Matsumoto M, Yamada T, Yoshinaga SK, et al. Essential role of NF-kappa B-inducing kinase in T cell activation through the TCR/CD3 pathway. J Immunol,2002,169 ( 3 ) : 1151-1158.
  • 4Kristian T. Metabolic stages, mitochondria, and calcium in hypoxic/ ischemic brain damage. Cell Calcium,2004,36(3-4) :221-233.
  • 5Fink MP. Bench-to-bedside review: Cytopathic hypoxia. Crit Care,2002,6(6) :491-499.
  • 6Wendel M,Heller AR, Koch T. Pathomechanism of organ failure. Mitochondrial dysfunction in sepsis. Anaesthesist, 2009,58 (4) :343-352.
  • 7Balestra GM,Legrand M, Ince C. Microciculation and mitochondria in sepsis:getting out of breath. Curt Opin Anaesthesiol,2009,22 (2) : 184-190.
  • 8Nakamori Y, Koh T, Ogura H, et al. Enhanced expression of intranuclear NF-kappa B in primed polymorphonuclear leukocytes in systemic inflammatory response syndrome patients. J Trauma, 2003,54 ( 2 ) : 253-260.
  • 9Mojsilovic-Petrovic J,Callaghan D, Cui H, et al. Hypoxia-inducible factor-1 ( HIF-1 ) is involved in the regulation of hypoxia-stimulated expression of monocyte chemoattractant protein-1 ( MCP-1/CCL2 ) and MCP-5 ( Cc112 ) in astrocytes. J Neuroinflammation ,2007,4 : 12.
  • 10Nijboer CH, Heijnen C J, Groenendaal F, et al. A dual role of the NF-κB pathway in neonatal hypoxic-ischemic brain damage. Stroke ,2008,39 ( 9 ) :2578-2593.

共引文献19

同被引文献108

引证文献5

二级引证文献20

国际儿科学杂志
2015年 第5期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部