摘要
乳铁蛋白(Lactoferrin,Lf)是分子量大小约为80 k Da的铁离子结合糖蛋白,是转铁蛋白(Transferrin,Tf)家族的成员之一。其理化性质独特,具有抑菌、抗病毒、抗癌、免疫调节、调节铁离子的吸收等诸多生物学功能。获得高产且有生物活性的重组乳铁蛋白,并用于临床治疗,一直是研究热点。随着基因工程技术的发展,已获得多个可表达重组乳铁蛋白的表达系统。本文对乳铁蛋白的理化性质、生物学活性、临床研究以及目前的重组表达系统进行综述,以期为乳铁蛋白的临床应用提供参考。
Lactoferrin is an iron-binding glycoprotein with a molecular weight of about 80 kDa that belongs to the transferrin family. Due to its unique physical and chemical properties, lactoferrin has a variety of biological functions in- eluding antibacterial, antiviral, anticancer, immunomodulatory activities and regulation of iron absorption. High-yield pro- duction of recombinant lactoferrin with biological activity and its application in clinical treatment have been a hot topic for long time. With the development of genetic engineering techniques, various expression systems have been developed to produce recombinant lactoferrin. In this review, we summarize physicochemical characteristics, biological activities, clinical studies and current recombinant expression systems of lactoferrin, in order to provide references for its clinical application.
出处
《遗传》
CAS
CSCD
北大核心
2015年第9期873-884,共12页
Hereditas（Beijing)
基金
药物化学生物学国家重点实验室开放基金(编号:201503017)
天津市应用基础与前沿技术研究计划重点项目(编号:112JCZDJC22900)
创新人才培养基金(编号:J1103503)资助
关键词
乳铁蛋白
抑菌
抗病毒
免疫调节
重组表达系统
lactoferrin
antibacterial
antiviral
immunomodulatory
recombinant expression system
