摘要
Na+-牛磺胆酸共转运多肽(NTCP)是第10个溶质转运蛋白(SLC10)家族成员之一,在胆汁酸的肠肝循环过程中发挥重要作用。NTCP的表达受细胞因子、细胞内胆汁酸浓度、激素水平等因素的影响;NTCP基因的单核苷酸多态性(SNP)与种族有关。现已确定NTCP是HBV的功能性受体,这一发现为抗乙肝新药的研发提供了新的靶点和策略,也改变了HBV领域的研究方向和模式。
The sodium-taurocholate cotransporting polypeptide （NTCP） is a member of the solute carrier 10 （SLC10） family and plays an important role in enterohepatic circulation of bile acids. The expression of NTCP is influenced by many factors such as cytokines, the intracellular concentration of bile acids, and hormone levels. SNPs of NTCP gene are related to ethnicity. NTCP has been identified as a functional receptor for the hepatitis B virus （HBV）. This finding has provided new targets and strategies for research and development of anti-HBV drugs and has changed the direction and manner of research into HBV.
出处
《中国病原生物学杂志》
CSCD
北大核心
2015年第7期655-658,共4页
Journal of Pathogen Biology
基金
国家自然科学基金项目(No.31370897)
泰安市科技发展计划资助项目(No.201540702)
关键词
Na+-牛磺胆酸共转运多肽
乙型肝炎病毒
乙型肝炎
综述
Sodium-taurocholate cotransporting polypeptide （NTCP）
hepatitis B virus （HBV）
hepatitis B
review
