摘要
目的：了解青霉素皮试阴性致过敏反应的相关因素,为临床安全、合理使用青霉素类药物提供参考。方法：检索中国知网（CNKI）、中文科技期刊数据库（维普,VIP）、中国生物医学期刊引文数据库和万方数据-数字化期刊群中报道的青霉素皮试阴性后所致过敏反应,对病人年龄、性别、原患疾病、过敏史、给药途径、合并用药情况、临床表现等信息进行分析。结果：在158例青霉素皮试阴性致过敏反应中,女性的构成比高于男性;21~40岁年龄段构成比高于其他年龄段;静脉滴注给药为最常见给药途径;临床表现以皮肤及其附件损害为主,严重者出现过敏性休克。结论：皮试阴性的病人使用青霉素治疗也应严密监护,以保障用药安全。
Objective： To investigate relevant factors of allergic reactions in patients with negative response to penicillin skin test, so as to provide reference for safe and rational use of penicillins clinically. Methods： Literature about allergic reactions with negative responses to penicillin skin test was retrieved in China Knowledge Resource Integrated Database（CNKI） ,Chinese Science and Technology Journal Database（VIP）, Chinese Medical Citation Index（CMCI） and Wanfang-Data-Digitalization. Ad- verse drug reactions（ADRs） cases were analyzed in the aspects of patients ＇ age, gender, primary diseases, allergic history, routes of medication, combined medication, clinical manifestations, etc. Results： In the 158 ADRs cases, the incidence of allergic reac- tions was higher in female than that in male. Patients at the age stage of 21-40 years had a higher incidence. The main route of administration was intravenous drip. The principal clinical manifestations of allergic reactions were lesions of skin and its appen- dix. Anaphylactic shock occurred in severe cases. Conclusion： Patients with negative response to skin test should also be closely monitored to ensure safety when they were administered with penieillins.
出处
《药学服务与研究》
CAS
2015年第4期294-298,共5页
Pharmaceutical Care and Research
关键词
青霉素
皮肤试验
药物副反应报告系统
综述
penicillin
skin tests
adverse drug reaction reporting system
review
