摘要
【目的】探讨脑源性神经生长因子（Brain derived neurotrophic factor,BDNF）及酪氨酸激酶受体 B （tyrosine kinase receptor B,TrkB）在子宫内膜癌（endometrial carcinoma,EC）中的表达及其意义。【方法】采用免疫组织化检测22例正常子宫内膜（正常组）、32例增生子宫内膜（增生组）、62例 EC 组织（EC 组）中的BDNF 及 TrkB 表达水平,并分析 EC 组织中 BDNF、TrkB 的表达与其临床病理特征的关系。【结果】增生组、EC 组 BDNF、TrkB 阳性表达率显著高于正常组,而 EC 组 BDNF、TrkB 阳性表达率显著高于增生组,差异均有统计学意义（P ＜0.05）。EC 组织中 BDNF、TrkB 的表达与肿瘤细胞分化程度、临床病理分期、肌层浸润深度、淋巴结转移的有无均显著相关（P ＜0.05）,且 EC 组织中 BDNF 与 TrkB 的表达具有显著相关性（r =0.508,P ＜0.05）。【结论】BDNF 及 TrkB 在 EC 的发生、发展中起重要作用,且两者相互促进。
[Objective]To explore the expressions of brain-derived neurotrophic factor （BDNF）and tyro-sine kinase receptor B （TrkB）in endometrial carcinoma and analyze their clinical significances.[Methods]The expressions of BDNF and TrkB were detected by immunohistochemistry in normal endometrium （n = 22）, hyperplasia endometrium （n =32）and endometrial carcinoma （n =62）.And the relationship with their clini-copathological characteristics were analyzed.[Results]BDNF and TrkB were negatively or weakly positively expressed in normal endometrium while positively in hyperplasia endometrium and endometrial carcinoma.And statistically significant differences existed among three groups （P 〈 0.05 ）.The expressions of BDNF and TrkB in endometrial carcinoma were significantly correlated with tumor cell differentiation,clinicopathologic staging,myometrial invasion and lymph node metastasis of endometrial carcinoma （P 〈0.05）.[Conclusion]The interaction of BDNF with TrkB may play an important synergistic role in the occurrence and development of endometrial carcinoma.
出处
《医学临床研究》
CAS
2015年第8期1477-1479,共3页
Journal of Clinical Research
基金
深圳市医学重点学科建设资助项目（2005C10）
