摘要
目的探讨鼻腔鼻窦鳞状细胞癌中增殖细胞核抗原(proliferating cell nuclear antigen,PCNA)和原癌基因蛋白质(oncogene protein,C-erb B-2)的表达情况及临床意义。方法利用免疫组织化学方法检测45例鼻腔鼻窦鳞癌的PCNA和C-erb B-2的表达情况,并选择15例正常鼻腔黏膜作为正常对照。结果各级鼻腔鼻窦鳞癌之中,PCNA和C-erb B-2均有表达,与正常对照鼻腔黏膜相比,差异均有统计学意义(P<0.05),且有随鳞癌分级升高表达不断增强的趋势。但在鳞癌中的表达,PCNA和C-erb B-2不存在显著的相关性。结论 PCNA和C-erb B-2的表达均能够反映出鼻腔鼻窦鳞状细胞癌的增殖活性,且其表达强度可以反映出鳞癌细胞的增殖活性高低。
Objective To explore the expression and clinical significance of proliferating cell nuclear antigen（ PCNA） and oncogene protein（ Cerb B-2） in the nasal cavity paranasal sinus squamous cell carcinoma. Method Expression of PCNA and C-erb B-2 were tested in 45 cases of the nasal cavity paranasal sinus squamous cell carcinoma by the immunohistochemical method,and 15 cases of normal nasal mucosa were selected as the normal control. Results All levels of sinonasal squamous cell carcinoma,PCNA and C-erb B-2 expressed in nasal mucosa,and compared with the normal control group,the differences were statistically significant（ P〈0. 05）,and with the increasing grade of squamous,cell carcinoma expression increased. But expression in squamous cell carcinoma,PCNA and C-erb B-2 had no significant correlation. Conclusion Expression of PCNA and C-erb B-2 can reflect the sinonasal squamous cell carcinoma proliferation activity,and the expression can reflect the proliferation activity of squamous cell carcinoma.
出处
《中国生化药物杂志》
CAS
2015年第1期94-96,共3页
Chinese Journal of Biochemical Pharmaceutics
关键词
鼻腔鼻窦鳞状细胞癌
增殖细胞核抗原
原癌基因蛋白质
sinus nasal squamous cell carcinoma
proliferating cell nuclear antigen
oncogene protein
